Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: Parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine
Copyright © 2014 by The American Society of Tropical Medicine and Hygiene. Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and...
Saved in:
Main Authors: | , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , , |
---|---|
Other Authors: | |
Format: | Article |
Published: |
2018
|
Subjects: | |
Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/34113 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Mahidol University |
id |
th-mahidol.34113 |
---|---|
record_format |
dspace |
institution |
Mahidol University |
building |
Mahidol University Library |
continent |
Asia |
country |
Thailand Thailand |
content_provider |
Mahidol University Library |
collection |
Mahidol University Institutional Repository |
topic |
Immunology and Microbiology Medicine |
spellingShingle |
Immunology and Microbiology Medicine Meera Venkatesan Nahla B. Gadalla Kasia Stepniewska Prabin Dahal Christian Nsanzabana Clarissa Moriera Ric N. Price Andreas Ma˚rtensson Philip J. Rosenthal Grant Dorsey Colin J. Sutherland Philippe Guérin Timothy M.E. Davis Didier Ménard Ishag Adam George Ademowo Cesar Arze Frederick N. Baliraine Nicole Berens-Riha Anders Björkman Steffen Borrmann Francesco Checchi Meghna Desai Mehul Dhorda Abdoulaye A. Djimdé Badria B. El-Sayed Teferi Eshetu Frederick Eyase Catherine Falade Jean Franc¸ois Faucher Gabrielle Fröberg Anastasia Grivoyannis Sally Hamour Sandrine Houzé Jacob Johnson Erasmus Kamugisha Simon Kariuki Jean René Kiechel Fred Kironde Poul Erik Kofoed Jacques LeBras Maja Malmberg Leah Mwai Billy Ngasala Francois Nosten Samuel L. Nsobya Alexis Nzila Mary Oguike Sabina Dahlström Otienoburu Bernhards Ogutu Jean Bosco Ouédraogo Patrice Piola Lars Rombo Birgit Schramm A. Fabrice Somé Julie Thwing Johan Ursing Rina P.M. Wong Ahmed Zeynudin Issaka Zongo Christopher V. Plowe Carol Hopkins Sibley Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: Parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine |
description |
Copyright © 2014 by The American Society of Tropical Medicine and Hygiene. Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P. falciparum multidrug resistance1 (pfmdr1) genes are associated with decreased sensitivity to amodiaquine and lumefantrine, but effects of these polymorphisms on therapeutic responses to artesunate-amodiaquine (ASAQ) and artemetherlumefantrine (AL) have not been clearly defined. Individual patient data from 31 clinical trials were harmonized and pooled by using standardized methods from the WorldWide Antimalarial Resistance Network. Data for more than 7,000 patients were analyzed to assess relationships between parasite polymorphisms in pfcrt and pfmdr1 and clinically relevant outcomes after treatment with AL or ASAQ. Presence of the pfmdr1 gene N86 (adjusted hazards ratio = 4.74, 95% confidence interval = 2.29-9.78, P < 0.001) and increased pfmdr1 copy number (adjusted hazards ratio = 6.52, 95% confidence interval = 2.36-17.97, P < 0.001) were significant independent risk factors for recrudescence in patients treated with AL. AL and ASAQ exerted opposing selective effects on single-nucleotide polymorphisms in pfcrt and pfmdr1. Monitoring selection and responding to emerging signs of drug resistance are critical tools for preserving efficacy of artemisinin combination therapies; determination of the prevalence of at least pfcrt K76T and pfmdr1 N86Y should now be routine. |
author2 |
University of Maryland School of Medicine |
author_facet |
University of Maryland School of Medicine Meera Venkatesan Nahla B. Gadalla Kasia Stepniewska Prabin Dahal Christian Nsanzabana Clarissa Moriera Ric N. Price Andreas Ma˚rtensson Philip J. Rosenthal Grant Dorsey Colin J. Sutherland Philippe Guérin Timothy M.E. Davis Didier Ménard Ishag Adam George Ademowo Cesar Arze Frederick N. Baliraine Nicole Berens-Riha Anders Björkman Steffen Borrmann Francesco Checchi Meghna Desai Mehul Dhorda Abdoulaye A. Djimdé Badria B. El-Sayed Teferi Eshetu Frederick Eyase Catherine Falade Jean Franc¸ois Faucher Gabrielle Fröberg Anastasia Grivoyannis Sally Hamour Sandrine Houzé Jacob Johnson Erasmus Kamugisha Simon Kariuki Jean René Kiechel Fred Kironde Poul Erik Kofoed Jacques LeBras Maja Malmberg Leah Mwai Billy Ngasala Francois Nosten Samuel L. Nsobya Alexis Nzila Mary Oguike Sabina Dahlström Otienoburu Bernhards Ogutu Jean Bosco Ouédraogo Patrice Piola Lars Rombo Birgit Schramm A. Fabrice Somé Julie Thwing Johan Ursing Rina P.M. Wong Ahmed Zeynudin Issaka Zongo Christopher V. Plowe Carol Hopkins Sibley |
format |
Article |
author |
Meera Venkatesan Nahla B. Gadalla Kasia Stepniewska Prabin Dahal Christian Nsanzabana Clarissa Moriera Ric N. Price Andreas Ma˚rtensson Philip J. Rosenthal Grant Dorsey Colin J. Sutherland Philippe Guérin Timothy M.E. Davis Didier Ménard Ishag Adam George Ademowo Cesar Arze Frederick N. Baliraine Nicole Berens-Riha Anders Björkman Steffen Borrmann Francesco Checchi Meghna Desai Mehul Dhorda Abdoulaye A. Djimdé Badria B. El-Sayed Teferi Eshetu Frederick Eyase Catherine Falade Jean Franc¸ois Faucher Gabrielle Fröberg Anastasia Grivoyannis Sally Hamour Sandrine Houzé Jacob Johnson Erasmus Kamugisha Simon Kariuki Jean René Kiechel Fred Kironde Poul Erik Kofoed Jacques LeBras Maja Malmberg Leah Mwai Billy Ngasala Francois Nosten Samuel L. Nsobya Alexis Nzila Mary Oguike Sabina Dahlström Otienoburu Bernhards Ogutu Jean Bosco Ouédraogo Patrice Piola Lars Rombo Birgit Schramm A. Fabrice Somé Julie Thwing Johan Ursing Rina P.M. Wong Ahmed Zeynudin Issaka Zongo Christopher V. Plowe Carol Hopkins Sibley |
author_sort |
Meera Venkatesan |
title |
Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: Parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine |
title_short |
Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: Parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine |
title_full |
Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: Parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine |
title_fullStr |
Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: Parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine |
title_full_unstemmed |
Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: Parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine |
title_sort |
polymorphisms in plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: parasite risk factors that affect treatment outcomes for p. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/34113 |
_version_ |
1763488437941305344 |
spelling |
th-mahidol.341132020-11-16T08:44:33Z Polymorphisms in Plasmodium falciparum chloroquine resistance transporter and multidrug resistance 1 genes: Parasite risk factors that affect treatment outcomes for P. falciparum malaria after artemether-lumefantrine and artesunate-amodiaquine Meera Venkatesan Nahla B. Gadalla Kasia Stepniewska Prabin Dahal Christian Nsanzabana Clarissa Moriera Ric N. Price Andreas Ma˚rtensson Philip J. Rosenthal Grant Dorsey Colin J. Sutherland Philippe Guérin Timothy M.E. Davis Didier Ménard Ishag Adam George Ademowo Cesar Arze Frederick N. Baliraine Nicole Berens-Riha Anders Björkman Steffen Borrmann Francesco Checchi Meghna Desai Mehul Dhorda Abdoulaye A. Djimdé Badria B. El-Sayed Teferi Eshetu Frederick Eyase Catherine Falade Jean Franc¸ois Faucher Gabrielle Fröberg Anastasia Grivoyannis Sally Hamour Sandrine Houzé Jacob Johnson Erasmus Kamugisha Simon Kariuki Jean René Kiechel Fred Kironde Poul Erik Kofoed Jacques LeBras Maja Malmberg Leah Mwai Billy Ngasala Francois Nosten Samuel L. Nsobya Alexis Nzila Mary Oguike Sabina Dahlström Otienoburu Bernhards Ogutu Jean Bosco Ouédraogo Patrice Piola Lars Rombo Birgit Schramm A. Fabrice Somé Julie Thwing Johan Ursing Rina P.M. Wong Ahmed Zeynudin Issaka Zongo Christopher V. Plowe Carol Hopkins Sibley University of Maryland School of Medicine National Institute of Allergy and Infectious Diseases Tropical Medicine Research Institute Sudan Nuffield Department of Clinical Medicine Menzies School of Health Research Karolinska Institutet University of California, San Francisco London School of Hygiene & Tropical Medicine University of Western Australia Faculty of Medicine and Dentistry Institut Pasteur du Cambodge University of Khartoum Faculty of Medicine University of Ibadan LeTourneau University Ludwig-Maximilians-Universitat Munchen Sveriges lantbruksuniversitet Wellcome Trust Research Laboratories Nairobi Magdeburg School of Medicine Save the Children Fund Centers for Disease Control and Prevention Epicentre University of Sciences Jimma University Kenya Medical Research Institute Besançon University Medical Center IRD Institut de Recherche pour le Developpement University of Washington, Seattle UCL Hopital Bichat-Claude-Bernard AP-HP Universite Paris Descartes Catholic University of Health and Allied Sciences-Bugando Drugs for Neglected Diseases Initiative Makerere University St. Augustine International University Projecto de Saúde de Bandim Kolding Sygehus The University of British Columbia Muhimbili University of Health and Allied Sciences Mahidol University King Fahd University of Petroleum and Minerals Bernard Hospital Centre MURAZ Institut Pasteur de Madagascar Immunology and Microbiology Medicine Copyright © 2014 by The American Society of Tropical Medicine and Hygiene. Adequate clinical and parasitologic cure by artemisinin combination therapies relies on the artemisinin component and the partner drug. Polymorphisms in the Plasmodium falciparum chloroquine resistance transporter (pfcrt) and P. falciparum multidrug resistance1 (pfmdr1) genes are associated with decreased sensitivity to amodiaquine and lumefantrine, but effects of these polymorphisms on therapeutic responses to artesunate-amodiaquine (ASAQ) and artemetherlumefantrine (AL) have not been clearly defined. Individual patient data from 31 clinical trials were harmonized and pooled by using standardized methods from the WorldWide Antimalarial Resistance Network. Data for more than 7,000 patients were analyzed to assess relationships between parasite polymorphisms in pfcrt and pfmdr1 and clinically relevant outcomes after treatment with AL or ASAQ. Presence of the pfmdr1 gene N86 (adjusted hazards ratio = 4.74, 95% confidence interval = 2.29-9.78, P < 0.001) and increased pfmdr1 copy number (adjusted hazards ratio = 6.52, 95% confidence interval = 2.36-17.97, P < 0.001) were significant independent risk factors for recrudescence in patients treated with AL. AL and ASAQ exerted opposing selective effects on single-nucleotide polymorphisms in pfcrt and pfmdr1. Monitoring selection and responding to emerging signs of drug resistance are critical tools for preserving efficacy of artemisinin combination therapies; determination of the prevalence of at least pfcrt K76T and pfmdr1 N86Y should now be routine. 2018-11-09T02:28:16Z 2018-11-09T02:28:16Z 2014-01-01 Article American Journal of Tropical Medicine and Hygiene. Vol.91, No.4 (2014), 833-843 10.4269/ajtmh.14-0031 00029637 2-s2.0-84906937961 https://repository.li.mahidol.ac.th/handle/123456789/34113 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=84906937961&origin=inward |