Tafenoquine plus chloroquine for the treatment and relapse prevention of Plasmodium vivax malaria (DETECTIVE): A multicentre, double-blind, randomised, phase 2b dose-selection study

• Main Authors: Alejandro Llanos-Cuentas, Marcus V. Lacerda, Ronnatrai Rueangweerayut, Srivicha Krudsood, Sandeep K. Gupta, Sanjay K. Kochar, Preetam Arthur, Nuttagarn Chuenchom, Jörg J. Möhrle, Stephan Duparc, Cletus Ugwuegbulam, Jörg Peter Kleim, Nick Carter, Justin A. Green, Lynda Kellam
• 其他作者: Universidad Peruana Cayetano Heredia
• 格式: Article
• 出版: 2018
• 主題: Medicine
• 在線閱讀: https://repository.li.mahidol.ac.th/handle/123456789/34830

Background Clinical eff ectiveness of previous regimens to treat Plasmodium vivax infection have been hampered by compliance. We aimed to assess the dose-response, safety, and tolerability of single-dose tafenoquine plus 3-day chloroquine for P vivax malaria radical cure. Methods In this double-blin...