Artemether-lumefantrine treatment of uncomplicated Plasmodium falciparum malaria: A systematic review and meta-analysis of day 7 lumefantrine concentrations and therapeutic response using individual patient data

• Main Authors: Elizabeth A. Ashley, Francesca Aweeka, Karen I. Barnes, Quique Bassat, Steffen Borrmann, Prabin Dahal, Timothy M.E. Davis, Mey Bouth Denis, Abdoulaye A. Djimde, Jean François Faucher, Blaise Genton, Philippe J. Guérin, Kamal Hamed, Eva Maria Hodel, Liusheng Huang, Vincent Jullien, Harin A. Karunajeewa, Jean René Kiechel, Poul Erik Kofoed, Gilbert Lefèvre, Niklas Lindegardh Lindegardh, Andreas Mårtensson, Mayfong Mayxay, Rose Mcgready, Clarissa Moreira, Paul N. Newton, Billy E. Ngasala, Francois Nosten, Christian Nsanzabana, Sunil Parikh, Patrice Piola, Ric N. Price, Pascal Ringwald, Lars Rombo, Birgit Schramm, Carol Hopkins Sibley, Kasia Stepniewska, Joel Tarning, Johan Ursing, Michele Van Vugt, Nicholas J. White, Lesley J. Workman, Philippe Deloron, Kevin Marsh
• Other Authors: Shoklo Malaria Research Unit
• Format: Article
• Published: 2018
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/36324
• Institution: Mahidol University

© 2015 WorldWide Antimalarial Resistance Network (WWARN) Lumefantrine PK/PD Study Group. Background: Achieving adequate antimalarial drug exposure is essential for curing malaria. Day 7 blood or plasma lumefantrine concentrations provide a simple measure of drug exposure that correlates well with ar...