Comparative Heterochromatin Profiling Reveals Conserved and Unique Epigenome Signatures Linked to Adaptation and Development of Malaria Parasites

• Main Authors: Sabine A. Fraschka, Michael Filarsky, Regina Hoo, Igor Niederwieser, Xue Yan Yam, Nicolas M.B. Brancucci, Franziska Mohring, Annals T. Mushunje, Ximei Huang, Peter R. Christensen, Francois Nosten, Zbynek Bozdech, Bruce Russell, Robert W. Moon, Matthias Marti, Peter R. Preiser, Richárd Bártfai, Till S. Voss
• Other Authors: Harvard School of Public Health
• Format: Article
• Published: 2019
• Subjects: Immunology and Microbiology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/46038
• Institution: Mahidol University

© 2018 The Authors Heterochromatin-dependent gene silencing is central to the adaptation and survival of Plasmodium falciparum malaria parasites, allowing clonally variant gene expression during blood infection in humans. By assessing genome-wide heterochromatin protein 1 (HP1) occupancy, we present...