Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns
© 2019, The Author(s). Estimates of Plasmodium falciparum migration may inform strategies for malaria elimination. Here we elucidate fine-scale parasite population structure and infer recent migration across Southeast Asia using identity-by-descent (IBD) approaches based on genome-wide single nucleo...
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th-mahidol.500272020-01-27T15:09:39Z Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns Amol C. Shetty Christopher G. Jacob Fang Huang Yao Li Sonia Agrawal David L. Saunders Chanthap Lon Mark M. Fukuda Pascal Ringwald Elizabeth A. Ashley Kay Thwe Han Tin Maung Hlaing Myaing M. Nyunt Joana C. Silva Kathleen E. Stewart Christopher V. Plowe Timothy D. O’Connor Shannon Takala-Harrison Harald Noedl Wasif A. Khan Paul Newton Myat P. Kyaw Nicholas J. White Arjen M. Dondorp Nicholas P. Day Charles J. Woodrow Mehul Dhorda M. Abul Faiz Rick M. Fairhurst Pharath Lim Rupam Tripura Mayfong Mayxay Ye Htut Francois Nosten Aung Pyae Phyo Sasithon Pukrittayakamee Tran Tinh Hien Nguyen Thanh Thuy Nhien Olugbenga A. Mokuolu Caterina I. Fanello Marie A. Onyamboko Medizinische Universitat Wien, Zentrum für Pathophysiologie, Infektiologie und Immunologie Chinese Center for Disease Control and Prevention Organisation Mondiale de la Santé University of Maryland National Institute of Allergy and Infectious Diseases Armed Forces Research Institute of Medical Sciences, Thailand University of Maryland School of Medicine Mahidol University University of Ilorin International Centre for Diarrhoeal Disease Research Bangladesh Nuffield Department of Clinical Medicine Duke University Wellcome Sanger Institute University of Health Sciences Malaria Research Group and Dev Care Foundation Lao-Oxford-Mahosot Hospital-Wellcome Trust Research Unit (LOMWRU) Defence Services Medical Research Centre Armed Forces Research Institute of Medical Sciences WorldWide Antimalarial Resistance Network Oxford University Clinical Research Unit (OUCRU) Ministry of Health Biochemistry, Genetics and Molecular Biology Chemistry © 2019, The Author(s). Estimates of Plasmodium falciparum migration may inform strategies for malaria elimination. Here we elucidate fine-scale parasite population structure and infer recent migration across Southeast Asia using identity-by-descent (IBD) approaches based on genome-wide single nucleotide polymorphisms called in 1722 samples from 54 districts. IBD estimates are consistent with isolation-by-distance. We observe greater sharing of larger IBD segments between artemisinin-resistant parasites versus sensitive parasites, which is consistent with the recent spread of drug resistance. Our IBD analyses reveal actionable patterns, including isolated parasite populations, which may be prioritized for malaria elimination, as well as asymmetrical migration identifying potential sources and sinks of migrating parasites. 2020-01-27T07:35:38Z 2020-01-27T07:35:38Z 2019-12-01 Article Nature Communications. Vol.10, No.1 (2019) 10.1038/s41467-019-10121-3 20411723 2-s2.0-85067602013 https://repository.li.mahidol.ac.th/handle/123456789/50027 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85067602013&origin=inward |
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Biochemistry, Genetics and Molecular Biology Chemistry Amol C. Shetty Christopher G. Jacob Fang Huang Yao Li Sonia Agrawal David L. Saunders Chanthap Lon Mark M. Fukuda Pascal Ringwald Elizabeth A. Ashley Kay Thwe Han Tin Maung Hlaing Myaing M. Nyunt Joana C. Silva Kathleen E. Stewart Christopher V. Plowe Timothy D. O’Connor Shannon Takala-Harrison Harald Noedl Wasif A. Khan Paul Newton Myat P. Kyaw Nicholas J. White Arjen M. Dondorp Nicholas P. Day Charles J. Woodrow Mehul Dhorda M. Abul Faiz Rick M. Fairhurst Pharath Lim Rupam Tripura Mayfong Mayxay Ye Htut Francois Nosten Aung Pyae Phyo Sasithon Pukrittayakamee Tran Tinh Hien Nguyen Thanh Thuy Nhien Olugbenga A. Mokuolu Caterina I. Fanello Marie A. Onyamboko Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns |
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© 2019, The Author(s). Estimates of Plasmodium falciparum migration may inform strategies for malaria elimination. Here we elucidate fine-scale parasite population structure and infer recent migration across Southeast Asia using identity-by-descent (IBD) approaches based on genome-wide single nucleotide polymorphisms called in 1722 samples from 54 districts. IBD estimates are consistent with isolation-by-distance. We observe greater sharing of larger IBD segments between artemisinin-resistant parasites versus sensitive parasites, which is consistent with the recent spread of drug resistance. Our IBD analyses reveal actionable patterns, including isolated parasite populations, which may be prioritized for malaria elimination, as well as asymmetrical migration identifying potential sources and sinks of migrating parasites. |
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Medizinische Universitat Wien, Zentrum für Pathophysiologie, Infektiologie und Immunologie |
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Medizinische Universitat Wien, Zentrum für Pathophysiologie, Infektiologie und Immunologie Amol C. Shetty Christopher G. Jacob Fang Huang Yao Li Sonia Agrawal David L. Saunders Chanthap Lon Mark M. Fukuda Pascal Ringwald Elizabeth A. Ashley Kay Thwe Han Tin Maung Hlaing Myaing M. Nyunt Joana C. Silva Kathleen E. Stewart Christopher V. Plowe Timothy D. O’Connor Shannon Takala-Harrison Harald Noedl Wasif A. Khan Paul Newton Myat P. Kyaw Nicholas J. White Arjen M. Dondorp Nicholas P. Day Charles J. Woodrow Mehul Dhorda M. Abul Faiz Rick M. Fairhurst Pharath Lim Rupam Tripura Mayfong Mayxay Ye Htut Francois Nosten Aung Pyae Phyo Sasithon Pukrittayakamee Tran Tinh Hien Nguyen Thanh Thuy Nhien Olugbenga A. Mokuolu Caterina I. Fanello Marie A. Onyamboko |
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Article |
author |
Amol C. Shetty Christopher G. Jacob Fang Huang Yao Li Sonia Agrawal David L. Saunders Chanthap Lon Mark M. Fukuda Pascal Ringwald Elizabeth A. Ashley Kay Thwe Han Tin Maung Hlaing Myaing M. Nyunt Joana C. Silva Kathleen E. Stewart Christopher V. Plowe Timothy D. O’Connor Shannon Takala-Harrison Harald Noedl Wasif A. Khan Paul Newton Myat P. Kyaw Nicholas J. White Arjen M. Dondorp Nicholas P. Day Charles J. Woodrow Mehul Dhorda M. Abul Faiz Rick M. Fairhurst Pharath Lim Rupam Tripura Mayfong Mayxay Ye Htut Francois Nosten Aung Pyae Phyo Sasithon Pukrittayakamee Tran Tinh Hien Nguyen Thanh Thuy Nhien Olugbenga A. Mokuolu Caterina I. Fanello Marie A. Onyamboko |
author_sort |
Amol C. Shetty |
title |
Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns |
title_short |
Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns |
title_full |
Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns |
title_fullStr |
Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns |
title_full_unstemmed |
Genomic structure and diversity of Plasmodium falciparum in Southeast Asia reveal recent parasite migration patterns |
title_sort |
genomic structure and diversity of plasmodium falciparum in southeast asia reveal recent parasite migration patterns |
publishDate |
2020 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/50027 |
_version_ |
1763492309932965888 |