Cadmium induces apoptotic program imbalance and cell cycle inhibitor expression in cultured human astrocytes

• Main Authors: Dusadee Ospondpant, Suttinee Phuagkhaopong, Kran Suknuntha, Kant Sangpairoj, Thitima Kasemsuk, Chutima Srimaroeng, Pornpun Vivithanaporn
• Other Authors: University of Wisconsin School of Medicine and Public Health
• Format: Article
• Published: 2020
• Subjects: Environmental Science
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/50945
• Institution: Mahidol University

© 2018 Elsevier B.V. Cadmium is a highly neurotoxic heavy metal impairing neurogenesis and induces neurodegenerative disorders. Toxic concentrations of cadmium induce astrocytic apoptosis by depleting intracellular glutathione levels, elevating intracellular calcium levels, altering mitochondria mem...