Intracellular nickel accumulation induces apoptosis and cell cycle arrest in human astrocytic cells

• Main Authors: Ruedeemars Yubolphan, Suttinee Phuagkhaopong, Kant Sangpairoj, Nathawut Sibmooh, Christopher Power, Pornpun Vivithanaporn
• Other Authors: University of Alberta, Faculty of Medicine and Dentistry
• Format: Article
• Published: 2022
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Materials Science
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/76302
• Institution: Mahidol University

Nickel, a heavy metal found in electronic wastes and fume from electronic cigarettes, induces neuronal cell death and is associated with neurocognitive impairment. Astrocytes are the first line of defense against nickel after entering the brain; however, the effects of nickel on astrocytes remain un...