Sequential open-label study of the safety, tolerability, and pharmacokinetic interactions between dihydroartemisinin-piperaquine and mefloquine in healthy Thai adults

• Main Authors: Borimas Hanboonkunupakarn, Rob W. Van Der Pluijm, Richard Hoglund, Sasithon Pukrittayakamee, Markus Winterberg, Mavuto Mukaka, Naomi Waithira, Kesinee Chotivanich, Pratap Singhasivanon, Nicholas J. White, Arjen M. Dondorp, Joel Tarning, Podjanee Jittamala
• Other Authors: Mahidol University
• Format: Article
• Published: 2020
• Subjects: Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/52329

© 2019 Hanboonkunupakarn et al. Artemisinin-based combination therapies (ACTs) have contributed substantially to the global decline in Plasmodium falciparum morbidity and mortality, but resistance to artemisinins and their partner drugs is increasing in Southeast Asia, threatening malaria control. N...