Inhibition of topoisomerase IIα and induction of DNA damage in cholangiocarcinoma cells by altholactone and its halogenated benzoate derivatives

Inhibition of topoisomerase IIα and induction of DNA damage in cholangiocarcinoma cells by altholactone and its halogenated benzoate derivatives

© 2020 The Author(s) Topoisomerase IIα enzyme (Topo IIα) plays a critical function in DNA replication process and is considered to be a promising target of anti-cancer drugs. In the present study, we reported that the altholactone derivatives modified by adding a halogenated benzoate group showed gr...

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Bibliographic Details
Main Authors: Sarunya Kitdumrongthum, Somrudee Reabroi, Kanoknetr Suksen, Patoomratana Tuchinda, Bamroong Munyoo, Panupong Mahalapbutr, Thanyada Rungrotmongkol, Puey Ounjai, Arthit Chairoungdua
Other Authors: Chulalongkorn University
Format: Article
Published: 2020
Subjects:
Pharmacology, Toxicology and Pharmaceutics
Online Access:https://repository.li.mahidol.ac.th/handle/123456789/54701
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Institution: Mahidol University

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https://repository.li.mahidol.ac.th/handle/123456789/54701

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