Inhibition of Tumor Growth against Chemoresistant Cholangiocarcinoma by a Proapoptotic Peptide Targeting Interleukin-4 Receptor

• Main Authors: Uttapol Permpoon, Fatima Khan, Sri Murugan Poonkavithai Vadevoo, Smriti Gurung, Gowri Rangaswamy Gunassekaran, Min Jong Kim, Sang Hyun Kim, Peti Thuwajit, Byungheon Lee
• Other Authors: Faculty of Medicine, Siriraj Hospital, Mahidol University
• Format: Article
• Published: 2020
• Subjects: Biochemistry, Genetics and Molecular Biology
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/59855
• Institution: Mahidol University

Cholangiocarcinoma (CCA) has a poor prognosis and high chemoresistance. Interleukin-4 receptor (IL-4R) is overexpressed in several cancer cells and plays a crucial role in tumor progression and drug resistance. IL4RPep-1, an IL-4R-binding peptide, has been identified by phage display and used for tu...