Triple Artemisinin-Based Combination Therapies for Malaria – A New Paradigm?
© 2020 The Authors Recent gains in the fight against malaria are threatened by the emergence and spread of artemisinin and partner drug resistance in Plasmodium falciparum in the Greater Mekong Subregion (GMS). When artemisinins are combined with a single partner drug, all recommended artemisinin-ba...
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th-mahidol.599982021-02-04T10:42:26Z Triple Artemisinin-Based Combination Therapies for Malaria – A New Paradigm? Rob W. van der Pluijm Chanaki Amaratunga Mehul Dhorda Arjen M. Dondorp Mahidol University Nuffield Department of Medicine Asia Regional Centre Immunology and Microbiology Medicine © 2020 The Authors Recent gains in the fight against malaria are threatened by the emergence and spread of artemisinin and partner drug resistance in Plasmodium falciparum in the Greater Mekong Subregion (GMS). When artemisinins are combined with a single partner drug, all recommended artemisinin-based combination therapies have shown reduced efficacy in some countries in the GMS at some point. Novel drugs are not available for the near future. Triple artemisinin-based combination therapies, combining artemisinins with two currently available partner drugs, will provide one of the last remaining safe and effective treatments for falciparum malaria that can be deployed rapidly in the GMS, whereas their deployment beyond the GMS could delay or prevent the global emergence and spread of resistance to currently available drugs. 2020-11-18T09:41:11Z 2020-11-18T09:41:11Z 2020-01-01 Review Trends in Parasitology. (2020) 10.1016/j.pt.2020.09.011 14715007 14714922 2-s2.0-85092462613 https://repository.li.mahidol.ac.th/handle/123456789/59998 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=85092462613&origin=inward |
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Immunology and Microbiology Medicine Rob W. van der Pluijm Chanaki Amaratunga Mehul Dhorda Arjen M. Dondorp Triple Artemisinin-Based Combination Therapies for Malaria – A New Paradigm? |
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© 2020 The Authors Recent gains in the fight against malaria are threatened by the emergence and spread of artemisinin and partner drug resistance in Plasmodium falciparum in the Greater Mekong Subregion (GMS). When artemisinins are combined with a single partner drug, all recommended artemisinin-based combination therapies have shown reduced efficacy in some countries in the GMS at some point. Novel drugs are not available for the near future. Triple artemisinin-based combination therapies, combining artemisinins with two currently available partner drugs, will provide one of the last remaining safe and effective treatments for falciparum malaria that can be deployed rapidly in the GMS, whereas their deployment beyond the GMS could delay or prevent the global emergence and spread of resistance to currently available drugs. |
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Mahidol University |
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Mahidol University Rob W. van der Pluijm Chanaki Amaratunga Mehul Dhorda Arjen M. Dondorp |
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Review |
author |
Rob W. van der Pluijm Chanaki Amaratunga Mehul Dhorda Arjen M. Dondorp |
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Rob W. van der Pluijm |
title |
Triple Artemisinin-Based Combination Therapies for Malaria – A New Paradigm? |
title_short |
Triple Artemisinin-Based Combination Therapies for Malaria – A New Paradigm? |
title_full |
Triple Artemisinin-Based Combination Therapies for Malaria – A New Paradigm? |
title_fullStr |
Triple Artemisinin-Based Combination Therapies for Malaria – A New Paradigm? |
title_full_unstemmed |
Triple Artemisinin-Based Combination Therapies for Malaria – A New Paradigm? |
title_sort |
triple artemisinin-based combination therapies for malaria – a new paradigm? |
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2020 |
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https://repository.li.mahidol.ac.th/handle/123456789/59998 |
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1763497343374589952 |