Sequence variation does not confound the measurement of plasma PfHRP2 concentration in African children presenting with severe malaria

• Main Authors: Thiranut Ramutton, Hendriksen, Ilse CE, Mwanga-Amumpaire, Juliet, Mtove, George, Olaosebikan, Rasaq, Tshefu, Antoinette K., Onyamboko, Marie A., Karema, Corine, Maitland, Kathryn, Gomes, Ermelinda, Gesase, Samwel, Reyburn, Hugh, Kamolrat Silamut, Kesinee Chotivanich, เกศินี โชติวานิช, Kamoltip Promnares, Fanello, Caterina I., Seidlein, Lorenz von, Day, Nicholas P.J., White, Nicholas J., Dondorp, Arjen M., Mallika Imwong, มัลลิกา อิ่มวงศ์, Woodrow, Charles J.
• Format: Article
• Language: English
• Published: 2013
• Subjects: Histidine-rich protein; Malaria; Severe; Tandem repeat; Falciparum; Open Access article
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/681
• Institution: Mahidol University

BACKGROUND: Plasmodium falciparum histidine-rich protein PFHRP2 measurement is used widely for diagnosis, and more recently for severity assessment in falciparum malaria. The Pfhrp2 gene is highly polymorphic, with deletion of the entire gene reported in both laboratory and field isolates. These...