Synbiotic supplementation improves obesity index and metabolic biomarkers in thai obese adults: A randomized clinical trial

• Main Authors: Chaiyavat Chaiyasut, Bhagavathi Sundaram Sivamaruthi, Periyanaina Kesika, Suchanat Khongtan, Nanticha Khampithum, Subramanian Thangaleela, Sartjin Peerajan, Akkarach Bumrungpert, Khontaros Chaiyasut, Sasithorn Sirilun, Phakkharawat Sittiprapaporn
• Other Authors: Chiang Mai Rajabhat University
• Format: Article
• Published: 2022
• Subjects: Agricultural and Biological Sciences; Health Professions; Immunology and Microbiology; Social Sciences
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/75628
• Institution: Mahidol University

The cluster of metabolic disorders includes obesity, dyslipidemia, hypertension, and glucose intolerance, increasing the risk of developing cardiovascular diseases and type 2 diabetes. Evolving proofs suggest an essential role of microbiota in human health and disease, including digestion, energy and glucose metabolism, immunomodulation, and brain function. The frequency of overweight is increasing, and the main causes for this are highly processed foods and less active lifestyles. Research is underway to unravel the probable relationship between obesity and intestinal microbiota. Here, we propose a method to understand and elucidate the synergistic function of prebiotics and probiotics in treating obesity. The biomarkers of obesity, such as cholesterol, gut permeability, oxidative stress, bacterial toxins, cytokines, and short-chain fatty acids, were analyzed in Thai obese individuals after being supplemented with a synbiotic preparation containing Lactobacillus paracasei, Bifidobacterium longum, Bifidobacterium breve, inulin, and fructooligosaccharide. The results reveal that the supplementation of synbiotics significantly altered the obesity-associated biomarkers in an appositive way. Further studies are warranted to use synbiotics as an adjuvant therapy for the management of obesity-related health issues.