Determination of Chinese hamster ovary (CHO) cell densities and antibody titers from small volumes of cell culture supernatants using multivariate analysis and partial least squares regression of UV-Vis spectra
Antibody titer and viable cell density (VCD) are two important parameters that need to be closely monitored during the process of cell line development and manufacturing of therapeutic antibodies. Typically, determination of each parameter requires 10–100 μL of supernatant sample, which is not suita...
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| Main Authors: | , , , , |
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| 格式: | Article |
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2022
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| 在線閱讀: | https://repository.li.mahidol.ac.th/handle/123456789/76050 |
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| 機構: | Mahidol University |