Plasmodium falciparum k13 mutations in africa and asia impact artemisinin resistance and parasite fitness

• Main Authors: Barbara H. Stokes, Satish K. Dhingra, Kelly Rubiano, Sachel Mok, Judith Straimer, Nina F. Gnädig, Ioanna Deni, Kyra A. Schindler, Jade R. Bath, Kurt E. Ward, Josefine Striepen, Tomas Yeo, Leila S. Ross, Eric Legrand, Frédéric Ariey, Clark H. Cunningham, Issa M. Souleymane, Adama Gansané, Romaric Nzoumbou-Boko, Claudette Ndayikunda, Abdunoor M. Kabanywanyi, Aline Uwimana, Samuel J. Smith, Olimatou Kolley, Mathieu Ndounga, Marian Warsame, Rithea Leang, François Nosten, Timothy J.C. Anderson, Philip J. Rosenthal, Didier Ménard, David A. Fidock
• Other Authors: Faculty of Tropical Medicine, Mahidol University
• Format: Article
• Published: 2022
• Subjects: Biochemistry, Genetics and Molecular Biology; Immunology and Microbiology; Neuroscience
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/76112
• Institution: Mahidol University

The emergence of mutant K13-mediated artemisinin (ART) resistance in Plasmodium falciparum malaria parasites has led to widespread treatment failures across Southeast Asia. In Africa, K13-propeller genotyping confirms the emergence of the R561H mutation in Rwanda and highlights the continuing domina...