Oxidative stress and protein damage responses mediate artemisinin resistance in malaria parasites

by Frances Rocamora, Lei Zhu, Kek Yee Liong, Arjen Dondorp, Olivo Miotto, Sachel Mok, Zbynek Bozdech
Published 2019

The transcriptome of Plasmodium vivax reveals divergence and diversity of transcriptional regulation in malaria parasites

by Zbynek Bozdech, Sachel Mok, Guangan Hu, Mallika Imwong, Anchalee Jaidee, Bruce Russell, Hagai Ginsburg, Francois Nosten, Nicholas P J Day, Nicholas J. White, Jane M. Carlton, Peter R. Preiser
Published 2018

Targeting the Cell Stress Response of Plasmodium falciparum to Overcome Artemisinin Resistance

by Con Dogovski, Stanley C. Xie, Gaetan Burgio, Jess Bridgford, Sachel Mok, James M. McCaw, Kesinee Chotivanich, Shannon Kenny, Nina Gnädig, Judith Straimer, Zbynek Bozdech, David A. Fidock, Julie A. Simpson, Arjen M. Dondorp, Simon Foote, Nectarios Klonis, Leann Tilley
Published 2018

Artemisinin resistance in Plasmodium falciparum is associated with an altered temporal pattern of transcription

by Sachel Mok, Mallika Imwong, Margaret J. Mackinnon, Joan Sim, Ramya Ramadoss, Poravuth Yi, Mayfong Mayxay, Kesinee Chotivanich, Kek Yee Liong, Bruce Russell, Duong Socheat, Paul N. Newton, Nicholas P.J. Day, Nicholas J. White, Peter R. Preiser, François Nosten, Arjen M. Dondorp, Zbynek Bozdech
Published 2018

The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background

by Lei Zhu, Jaishree Tripathi, Frances Maureen Rocamora, Olivo Miotto, Rob van der Pluijm, Till S. Voss, Sachel Mok, Dominic P. Kwiatkowski, François Nosten, Nicholas P.J. Day, Nicholas J. White, Arjen M. Dondorp, Zbynek Bozdech, Aung Pyae Phyo, Elizabeth A. Ashley, Frank Smithuis, Khin Lin, Kyaw Myo Tun, M. Abul Faiz, Mayfong Mayxay, Mehul Dhorda, Nguyen Thanh Thuy-Nhien, Paul N. Newton, Sasithon Pukrittayakamee, Tin M. Hlaing, Tran Tinh Hien, Ye Htut
Published 2019

Plasmodium falciparum k13 mutations in africa and asia impact artemisinin resistance and parasite fitness

by Barbara H. Stokes, Satish K. Dhingra, Kelly Rubiano, Sachel Mok, Judith Straimer, Nina F. Gnädig, Ioanna Deni, Kyra A. Schindler, Jade R. Bath, Kurt E. Ward, Josefine Striepen, Tomas Yeo, Leila S. Ross, Eric Legrand, Frédéric Ariey, Clark H. Cunningham, Issa M. Souleymane, Adama Gansané, Romaric Nzoumbou-Boko, Claudette Ndayikunda, Abdunoor M. Kabanywanyi, Aline Uwimana, Samuel J. Smith, Olimatou Kolley, Mathieu Ndounga, Marian Warsame, Rithea Leang, François Nosten, Timothy J.C. Anderson, Philip J. Rosenthal, Didier Ménard, David A. Fidock
Published 2022

The antimalarial MMV688533 provides potential for single-dose cures with a high barrier to Plasmodium falciparum parasite resistance

by James M. Murithi, Cécile Pascal, Jade Bath, Xavier Boulenc, Nina F. Gnädig, Charisse Flerida A. Pasaje, Kelly Rubiano, Tomas Yeo, Sachel Mok, Sylvie Klieber, Paul Desert, María Belén Jiménez-Díaz, Jutta Marfurt, Mélanie Rouillier, Mohammed H. Cherkaoui-Rbati, Nathalie Gobeau, Sergio Wittlin, Anne Catrin Uhlemann, Ric N. Price, Grennady Wirjanata, Rintis Noviyanti, Patrick Tumwebaze, Roland A. Cooper, Philip J. Rosenthal, Laura M. Sanz, Francisco Javier Gamo, Jayan Joseph, Shivendra Singh, Sridevi Bashyam, Jean Michel Augereau, Elie Giraud, Tanguy Bozec, Thierry Vermat, Gilles Tuffal, Jean Michel Guillon, Jérôme Menegotto, Laurent Sallé, Guillaume Louit, Marie José Cabanis, Marie Françoise Nicolas, Michel Doubovetzky, Rita Merino, Nadir Bessila, Iñigo Angulo-Barturen, Delphine Baud, Lidiya Bebrevska, Fanny Escudié, Jacquin C. Niles, Benjamin Blasco, Simon Campbell, Gilles Courtemanche, Laurent Fraisse, Alain Pellet, David A. Fidock, Didier Leroy
Published 2022