The origins of malaria artemisinin resistance defined by a genetic and transcriptomic background

• Main Authors: Lei Zhu, Jaishree Tripathi, Frances Maureen Rocamora, Olivo Miotto, Rob van der Pluijm, Till S. Voss, Sachel Mok, Dominic P. Kwiatkowski, François Nosten, Nicholas P.J. Day, Nicholas J. White, Arjen M. Dondorp, Zbynek Bozdech, Aung Pyae Phyo, Elizabeth A. Ashley, Frank Smithuis, Khin Lin, Kyaw Myo Tun, M. Abul Faiz, Mayfong Mayxay, Mehul Dhorda, Nguyen Thanh Thuy-Nhien, Paul N. Newton, Sasithon Pukrittayakamee, Tin M. Hlaing, Tran Tinh Hien, Ye Htut
• Other Authors: Columbia University Medical Center
• Format: Article
• Published: 2019
• Subjects: Biochemistry, Genetics and Molecular Biology; Chemistry; Physics and Astronomy
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/44991
• Institution: Mahidol University

© 2018, The Author(s). The predisposition of parasites acquiring artemisinin resistance still remains unclear beyond the mutations in Pfk13 gene and modulation of the unfolded protein response pathway. To explore the chain of casualty underlying artemisinin resistance, we reanalyze 773 P. falciparum...