Longitudinal ex vivo and molecular trends of chloroquine and piperaquine activity against Plasmodium falciparum and P. vivax before and after introduction of artemisinin-based combination therapy in Papua, Indonesia

• Main Authors: Jutta Marfurt, Grennady Wirjanata, Pak Prayoga, Ferryanto Chalfein, Leo Leonardo, Boni F. Sebayang, Dwi Apriyanti, Maic A.E.M. Sihombing, Leily Trianty, Rossarin Suwanarusk, Alan Brockman, Kim A. Piera, Irene Luo, Angela Rumaseb, Barbara MacHunter, Sarah Auburn, Nicholas M. Anstey, Enny Kenangalem, Rintis Noviyanti, Bruce Russell, Jeanne R. Poespoprodjo, Ric N. Price
• Other Authors: Eijkman Institute for Molecular Biology
• Format: Article
• Published: 2022
• Subjects: Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/77168
• Institution: Mahidol University

Drug resistant Plasmodium parasites are a major threat to malaria control and elimination. After reports of high levels of multidrug resistant P. falciparum and P. vivax in Indonesia, in 2005, the national first-line treatment policy for uncomplicated malaria was changed in March 2006, to dihydroart...