Semimechanistic pharmacokinetic and pharmacodynamic modeling of piperaquine in a volunteer infection study with plasmodium falciparum blood-stage Malaria

• Main Authors: Thanaporn Wattanakul, Mark Baker, Joerg Mohrle, Brett McWhinney, Richard M. Hoglund, James S. McCarthy, Joel Tarning
• Other Authors: Faculty of Tropical Medicine, Mahidol University
• Format: Article
• Published: 2022
• Subjects: Medicine; Pharmacology, Toxicology and Pharmaceutics
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/78312
• Institution: Mahidol University

Dihydroartemisinin-piperaquine is a recommended first-line artemisinin combination therapy for Plasmodium falciparum malaria. Piperaquine is also under consideration for other antimalarial combination therapies. The aim of this study was to develop a pharmacokinetic-pharmacodynamic model that might...