3, 4-diaminopyridine reverses respiratory paralysis induced by a presynaptically active snake venom and its major neurotoxin

• Main Authors: George Watt, C. D. Smith, A. Kaewsupo, T. M.E. Davis
• Other Authors: Armed Forces Research Institute of Medical Sciences, Thailand
• Format: Article
• Published: 2018
• Subjects: Immunology and Microbiology; Medicine
• Online Access: https://repository.li.mahidol.ac.th/handle/123456789/9600
• Institution: Mahidol University

Presynaptically active snake venom neurotoxins induce a potentially fatal neuromuscular blockade which cannotbe reliably overcome by current therapy. The drug 3, 4-diaminopyridine (DAP) is effective in other presynaptic paralytic conditions and was therefore tried in anaesthetized rabbits with respi...