Cardiovascular effects of piperine in anaesthesized dogs
Cardiovascular responses to intravenous administration of piperine were investigated in anaesthetized dogs. Piperine produced biphasic effects on the arterial blood pressure, depressor and pressor effects. In the presence of vagus nerves, low doses of piperine (0.25-0.5 mg kg -1 ) caused a transient...
Saved in:
Main Authors: | , , |
---|---|
Other Authors: | |
Format: | Article |
Published: |
2018
|
Subjects: | |
Online Access: | https://repository.li.mahidol.ac.th/handle/123456789/9865 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Mahidol University |
id |
th-mahidol.9865 |
---|---|
record_format |
dspace |
spelling |
th-mahidol.98652018-02-27T11:30:00Z Cardiovascular effects of piperine in anaesthesized dogs U. Hatthakit K. K. Shida Pang P. Piyachaturawat Mahidol University Pharmacology, Toxicology and Pharmaceutics Cardiovascular responses to intravenous administration of piperine were investigated in anaesthetized dogs. Piperine produced biphasic effects on the arterial blood pressure, depressor and pressor effects. In the presence of vagus nerves, low doses of piperine (0.25-0.5 mg kg -1 ) caused a transient drop in arterial blood pressure, a marked bradycardia and apnea. With higher doses of piperine (1.0-1.5 mg kg -1 ), a transient drop in blood pressure was followed by an overshoot of pressure and then a rapid return to normal. Bilateral vagotomy or atropine injection (1.0 mg kg -1 ) abolished the bradycardia and the fall of blood pressure caused by piperine. Regarding the pressor effect, piperine produced a positive inotropic effect with no chronotropic action. Verapamil (0.15 mg kg -1 ), a calcium channel blocking agent, completely abolished the overshoot of blood pressure. These results suggest that the depressor effect of piperine is associated with a cholinergic mechanism whereas the pressor effect is related to an influx of Ca ++ into the muscle cells probably into the cardiac and vascular smooth muscle cells. 2018-02-27T04:30:00Z 2018-02-27T04:30:00Z 1994-01-01 Article Asia Pacific Journal of Pharmacology. Vol.9, No.2 (1994), 79-82 02179687 2-s2.0-0028043277 https://repository.li.mahidol.ac.th/handle/123456789/9865 Mahidol University SCOPUS https://www.scopus.com/inward/record.uri?partnerID=HzOxMe3b&scp=0028043277&origin=inward |
institution |
Mahidol University |
building |
Mahidol University Library |
continent |
Asia |
country |
Thailand Thailand |
content_provider |
Mahidol University Library |
collection |
Mahidol University Institutional Repository |
topic |
Pharmacology, Toxicology and Pharmaceutics |
spellingShingle |
Pharmacology, Toxicology and Pharmaceutics U. Hatthakit K. K. Shida Pang P. Piyachaturawat Cardiovascular effects of piperine in anaesthesized dogs |
description |
Cardiovascular responses to intravenous administration of piperine were investigated in anaesthetized dogs. Piperine produced biphasic effects on the arterial blood pressure, depressor and pressor effects. In the presence of vagus nerves, low doses of piperine (0.25-0.5 mg kg -1 ) caused a transient drop in arterial blood pressure, a marked bradycardia and apnea. With higher doses of piperine (1.0-1.5 mg kg -1 ), a transient drop in blood pressure was followed by an overshoot of pressure and then a rapid return to normal. Bilateral vagotomy or atropine injection (1.0 mg kg -1 ) abolished the bradycardia and the fall of blood pressure caused by piperine. Regarding the pressor effect, piperine produced a positive inotropic effect with no chronotropic action. Verapamil (0.15 mg kg -1 ), a calcium channel blocking agent, completely abolished the overshoot of blood pressure. These results suggest that the depressor effect of piperine is associated with a cholinergic mechanism whereas the pressor effect is related to an influx of Ca ++ into the muscle cells probably into the cardiac and vascular smooth muscle cells. |
author2 |
Mahidol University |
author_facet |
Mahidol University U. Hatthakit K. K. Shida Pang P. Piyachaturawat |
format |
Article |
author |
U. Hatthakit K. K. Shida Pang P. Piyachaturawat |
author_sort |
U. Hatthakit |
title |
Cardiovascular effects of piperine in anaesthesized dogs |
title_short |
Cardiovascular effects of piperine in anaesthesized dogs |
title_full |
Cardiovascular effects of piperine in anaesthesized dogs |
title_fullStr |
Cardiovascular effects of piperine in anaesthesized dogs |
title_full_unstemmed |
Cardiovascular effects of piperine in anaesthesized dogs |
title_sort |
cardiovascular effects of piperine in anaesthesized dogs |
publishDate |
2018 |
url |
https://repository.li.mahidol.ac.th/handle/123456789/9865 |
_version_ |
1763491368717516800 |