A first-in-human randomized, double-blind, placebo-controlled, single- and multiple-ascending oral dose study of novel imidazolopiperazine KAF156 to assess its safety, tolerability...

by Leong, F.J, Zhao, R, Zeng, S, Magnusson, B, Diagana, T.T, Pertel, P
Published 2020

A first-in-human randomized, double-blind, placebo-controlled, single- And multiple-ascending oral dose study of novel antimalarial spiroindolone KAE609 (cipargamin) to assess its...

by Leong, F.J, Li, R, Jain, J.P, Lefèvre, G, Magnusson, B, Diagana, T.T, Partel, P
Published 2020

Pharmacokinetic-pharmacodynamic analysis of spiroindolone analogs and KAE609 in a murine malaria model

by Lakshminarayana S.B., Freymond C., Fischli C., Yu J., Weber S., Goh A., Yeung B.K.S., Ho, Chi Lui Paul, Dartois V., Diagana T.T., Rottmann M., Blasco F.
Published 2016

Imidazolopiperazines kill both rings and dormant rings in wild-type and K13 artemisinin-resistant plasmodium falciparum In Vitro

by Laurent Dembele, Devendra Kumar Gupta, Michelle Yi Xiu Lim, Xiaoman Ang, Jeremy J. Selva, Kesinee Chotivanich, Chea Nguon, Arjen M. Dondorp, Ghislain M.C. Bonamy, Thierry T. Diagana, Pablo Bifania
Published 2019

Imidazolopiperazines kill both rings and dormant rings in wild-type and K13 artemisinin-resistant plasmodium falciparum In Vitro

by Dembele, L, Gupta, D.K, Lim, M.Y.-X, Ang, X, Selva, J.J, Chotivanich, K, Nguon, C, Dondorp, A.M, Bonamy, G.M.C, Diagana, T.T, Bifania, P
Published 2020

Spiroindolone KAE609 for falciparum and vivax malaria

by Nicholas J. White, Sasithon Pukrittayakamee, Aung Pyae Phyo, Ronnatrai Rueangweerayut, François Nosten, Podjanee Jittamala, Atthanee Jeeyapant, Jay Prakash Jain, Gilbert Lefèvre, Ruobing Li, Baldur Magnusson, Thierry T. Diagana, F. Joel Leong
Published 2018

PI4 kinase is a prophylactic but not radical curative target in Plasmodium vivax-type malaria parasites

by Zeeman, A.-M, Lakshminarayana, S.B, Van Der Werff, N, Klooster, E.J, Voorberg-Van Der Wel, A, Kondreddi, R.R, Bodenreider, C, Simon, O, Sauerwein, R, Yeung, B.K.S, Diagana, T.T, Kocken, C.H.M
Published 2020

The plasmodium liver-specific protein 2 (LISP2) is an early marker of liver stage development

by Gupta, D.K., Dembele, L., Voorberg-Van Der Wel, A., Roma, G., Yip, A., Chuenchob, V., Kangwanrangsan, N., Ishino, T., Vaughan, A.M., Kappe, S.H., Flannery, E.L., Sattabongko, J., Mikolajczak, S., Bifani, P., Kocken, C.H.M., Diagana, T.T.
Published 2021

The Plasmodium PI(4)K inhibitor KDU691 selectively inhibits dihydroartemisinin-pretreated Plasmodium falciparum ring-stage parasites

by Dembele, L, Ang, X, Chavchich, M, Bonamy, G.M.C, Selva, J.J, Lim, M.Y.-X, Bodenreider, C, Yeung, B.K.S, Nosten, F, Russell, B.M, Edstein, M.D, Straimer, J, Fidock, D.A, Diagana, T.T, Bifani, P
Published 2020

The plasmodium liver-specific protein 2 (LISP2) is an early marker of liver stage development

by Devendra Kumar Gupta, Laurent Dembele, Annemarie Voorberg-Van Der Wel, Guglielmo Roma, Andy Yip, Vorada Chuenchob, Niwat Kangwanrangsan, Tomoko Ishino, Ashley M. Vaughan, Stefan H. Kappe, Erika L. Flannery, Jetsumon Sattabongko, Sebastian Mikolajczak, Pablo Bifani, Clemens H.M. Kocken, Thierry Tidiane Diagana
Published 2020

Antimalarial activity of KAF156 in falciparum and vivax malaria

by Nicholas J. White, Tran T. Duong, Chirapong Uthaisin, Fran'ois Nosten, Aung P. Phyo, Borimas Hanboonkunupakarn, Sasithon Pukrittayakamee, Podjanee Jittamala, Kittiphum Chuthasmit, Ming S. Cheung, Yiyan Feng, Ruobing Li, Baldur Magnusson, Marc Sultan, Daniela Wieser, Xiaolei Xun, Rong Zhao, Thierry T. Diagana, Peter Pertel, F. Joel Leong
Published 2018

Hepatic spheroids used as an in vitro model to study malaria relapse

by Adeline C.Y. Chua, Abhishek Ananthanarayanan, Jessica Jie Ying Ong, Jen Yi Wong, Andy Yip, Nisha Hari Singh, Yinghua Qu, Laurent Dembele, Michael McMillian, Ratawan Ubalee, Silas Davidson, Anchalee Tungtaeng, Rawiwan Imerbsin, Kapish Gupta, Chiara Andolina, Fan Lee, Kevin S-W Tan, François Nosten, Bruce Russell, Amber Lange, Thierry T. Diagana, Laurent Rénia, Bryan K.S. Yeung, Hanry Yu, Pablo Bifani
Published 2020

Direct inhibitors of InhA are active against Mycobacterium tuberculosis

by Manjunatha, Ujjini Havaldar, Rao, Srinivasa P S, Kondreddi, Ravinder Reddy Eddy, Noble, Christian G, Camacho, Luis Reinaldo, Tan, Bee H, Ng, Seowhwee, Ng, Pearlyshuyi, Ma, Ng L, Lakshminarayana, Suresh B., Herve, Maxime R., Barnes, Susan W, Yu, Weixuan, Kuhen, Kelli L, Blasco, Francesca, Beer, David, Walker, John R, Tonge, Peter J, Glynne, Richard J, Smith, Paul W, Diagana, Thierry Tidiane
Published 2016

UDP-galactose and acetyl-CoA transporters as Plasmodium multidrug resistance genes

by Lim, Michelle Yi-Xiu, LaMonte, Gregory, Lee, Marcus CS, Reimer, Christin, Tan, Bee Huat, Corey, Victoria, Tjahjadi, Bianca F, Chua, Adeline, Nachon, Marie, Wintjens, Rene, Gedeck, Peter, Malleret, Benoit, Renia, Laurent, Bonamy, Ghislain MC, Ho, Paul Chi-Lui, Yeung, Bryan KS, Chow, Eric D, Lim, Liting, Fidock, David A, Diagana, Thierry T, Winzeler, Elizabeth A, Bifani, Pablo
Published 2022

Hepatic spheroids used as an in vitro model to study malaria relapse

by Chua, Adeline CY, Ananthanarayanan, Abhishek, Ong, Jessica Jie Ying, Wong, Jen Yi, Yip, Andy, Singh, Nisha Hari, Qu, Yinghua, Dembele, Laurent, McMillian, Michael, Ubalee, Ratawan, Davidson, Silas, Tungtaeng, Anchalee, Imerbsin, Rawiwan, Gupta, Kapish, Andolina, Chiara, Lee, Fan, Tan, Kevin S-W, Nosten, Francois, Russell, Bruce, Lange, Amber, Diagana, Thierry T, Renia, Laurent, Yeung, Bryan KS, Yu, Hanry, Bifani, Pablo
Published 2020

Transcriptomic analysis reveals reduced transcriptional activity in the malaria parasite Plasmodium cynomolgi during progression into dormancy

by Nicole L. Bertschi, Annemarie Voorberg-Van der Wel, Anne Marie Zeeman, Sven Schuierer, Florian Nigsch, Walter Carbone, Judith Knehr, Devendra K. Gupta, Sam O. Hofman, Nicole van der Werff, Ivonne Nieuwenhuis, Els Klooster, Bart W. Faber, Erika L. Flannery, Sebastian A. Mikolajczak, Vorada Chuenchob, Binesh Shrestha, Martin Beibel, Tewis Bouwmeester, Niwat Kangwanrangsan, Jetsumon Sattabongkot, Thierry T. Diagana, Clemens H.M. Kocken, Guglielmo Roma
Published 2019

Spiroindolones, a potent compound class for the treatment of malaria

by Matthias Rottmann, Case McNamara, Bryan K.S. Yeung, Marcus C.S. Lee, Bin Zou, Bruce Russell, Patrick Seitz, David M. Plouffe, Neekesh V. Dharia, Jocelyn Tan, Steven B. Cohen, Kathryn R. Spencer, Gonzalo E. González-Páez, Suresh B. Lakshminarayana, Anne Goh, Rossarin Suwanarusk, Timothy Jegla, Esther K. Schmitt, Hans Peter Beck, Reto Brun, Francois Nosten, Laurent Renia, Veronique Dartois, Thomas H. Keller, David A. Fidock, Elizabeth A. Winzeler, Thierry T. Diagana
Published 2018

KAI407, a potent non-8-aminoquinoline compound that kills Plasmodium cynomolgi early dormant liver stage parasites in vitro

by Zeeman, A.-M, Van Amsterdam, S.M, McNamara, C.W, Voorberg-van Der Wel, A, Klooster, E.J, Van Den Berg, A, Remarque, E.J, Plouffe, D.M, Van Gemert, G.-J, Luty, A, Sauerwein, R, Gagaring, K, Borboa, R, Chen, Z, Kuhen, K, Glynne, R.J, Chatterjee, A.K, Nagle, A, Roland, J, Winzeler, E.A, Leroy, D, Campo, B, Diagana, T.T, Yeung, B.K.S, Thomas, A.W, Kocken, C.H.M
Published 2020

Robust continuous in vitro culture of the Plasmodium cynomolgi erythrocytic stages

by Chua, A.C.Y., Ong, J.J.Y., Malleret, B., Suwanarusk, R., Kosaisavee, V., Zeeman, A.-M., Cooper, C.A., Tan, K.S.W., Zhang, R., Tan, B.H., Abas, S.N., Yip, A., Elliot, A., Joyner, C.J., Cho, J.S., Breyer, K., Baran, S., Lange, A., Maher, S.P., Nosten, F., Bodenreider, C., Yeung, B.K.S., Mazier, D., Galinski, M.R., Dereuddre-Bosquet, N., Le Grand, R., Kocken, C.H.M., Rénia, L., Kyle, D.E., Diagana, T.T., Snounou, G., Russell, B., Bifani, P.
Published 2021

Robust continuous in vitro culture of the Plasmodium cynomolgi erythrocytic stages

by Adeline C.Y. Chua, Jessica Jie Ying Ong, Benoit Malleret, Rossarin Suwanarusk, Varakorn Kosaisavee, Anne Marie Zeeman, Caitlin A. Cooper, Kevin S.W. Tan, Rou Zhang, Bee Huat Tan, Siti Nurdiana Abas, Andy Yip, Anne Elliot, Chester J. Joyner, Jee Sun Cho, Kate Breyer, Szczepan Baran, Amber Lange, Steven P. Maher, François Nosten, Christophe Bodenreider, Bryan K.S. Yeung, Dominique Mazier, Mary R. Galinski, Nathalie Dereuddre-Bosquet, Roger Le Grand, Clemens H.M. Kocken, Laurent Rénia, Dennis E. Kyle, Thierry T. Diagana, Georges Snounou, Bruce Russell, Pablo Bifani
Published 2020