Thyroid hormone-mediated autophagy and mitochondrial turnover in NAFLD

by Sinha, R.A, Yen, P.M
Published 2020

Novel transcriptional mechanisms for regulating metabolism by thyroid hormone

by Singh, B.K, Sinha, R.A, Yen, P.M
Published 2020

Thyroid hormone negatively regulates CDX2 and SOAT2 mRNA expression via induction of miRNA-181d in hepatic cells

by Yap, C.S., Sinha, R.A., Ota, S., Katsuki, M., Yen, P.M.
Published 2016

Resveratrol induces insulin gene expression in mouse pancreatic ?-cells

by Xie, S, Sinha, R.A, Singh, B.K, Li, G.D, Han, W, Yen, P.M
Published 2020

Metabolomic analysis shows differential hepatic effects of T 2 and T 3 in rats after short-term feeding with high fat diet

by Iannucci, L.F, Cioffi, F, Senese, R, Goglia, F, Lanni, A, Yen, P.M, Sinha, R.A
Published 2020

FoxO1 deacetylation regulates thyroid hormone-induced transcription of key hepatic gluconeogenic genes

by Singh, B.K., Sinha, R.A., Zhou, J., Xie, S.Y., You, S.-H., Gauthier, K., Yen, P.M.
Published 2014

Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by vitamin B supplementation

by Tripathi, M, Zhang, C.W, Singh, B.K, Sinha, R.A, Moe, K.T, Desilva, D.A, Yen, P.M
Published 2020

Renal endoplasmic reticulum stress is coupled to impaired autophagy in a mouse model of GSD Ia

by Farah B.L., Landau D.J., Wu Y., Sinha R.A., Loh A., Bay B.-H., Koeberl D.D., Yen P.M.
Published 2020

Thyroid hormone stimulation of autophagy is essential for mitochondrial biogenesis and activity in skeletal muscle

by Lesmana R., Sinha R.A., Singh B.K., Zhou J., Ohba K., Wu Y., Yau W.W., Bay B.-H., Yen P.M.
Published 2020

Desensitization and incomplete recovery of hepatic target genes after chronic thyroid hormone treatment and withdrawal in male adult mice

by Ohba K., Leow M.K.-S., Singh B.K., Sinha R.A., Lesmana R., Liao X.-H., Ghosh S., Refetoff S., Sng J.C.G., Yen P.M.
Published 2020

Hepatic mitochondrial dysfunction is a feature of Glycogen Storage Disease Type Ia (GSDIa)

by Farah B.L., Sinha R.A., Wu Y., Singh B.K., Lim A., Hirayama M., Landau D.J., Bay B.H., Koeberl D.D., Yen P.M.
Published 2020

Genetic and bioinformatic analyses of the expression and function of PI3K regulatory subunit PIK3R3 in an Asian patient gastric cancer library

by Zhou, J., Chen, G.B., Tang, Y.C., Sinha, R.A., Wu, Y., Yap, C.S., Wang, G., Hu, J., Xia, X., Tan, P., Goh, L.K., Yen, P.M.
Published 2014

Induction of autophagy improves hepatic lipid metabolism in glucose-6-phosphatase deficiency

by Farah B.L., Landau D.J., Sinha R.A., Brooks E.D., Wu Y., Fung S.Y.S., Tanaka T., Hirayama M., Bay B.-H., Koeberl D.D., Yen P.M.
Published 2020

Changes in hepatic TRβ protein expression, lipogenic gene expression, and long-chain acylcarnitine levels during chronic hyperthyroidism and triiodothyronine withdrawal in a mouse...

by Ohba K., Sinha R.A., Singh B.K., Iannucci L.F., Zhou J., Kovalik J.-P., Liao X.-H., Refetoff S., Sng J.C.G., Leow M.K.-S., Yen P.M.
Published 2020

Thyroid hormone stimulates hepatic lipid catabolism via activation of autophagy

by Sinha, R.A., You, S.-H., Zhou, J., Siddique, M.M., Bay, B.-H., Zhu, X., Privalsky, M.L., Cheng, S.-Y., Stevens, R.D., Summers, S.A., Newgard, C.B., Lazar, M.A., Yen, P.M.
Published 2014

Titin truncations lead to impaired cardiomyocyte autophagy and mitochondrial function in vivo

by Zhou J, Ng B., Ko N.S.J., Fiedler L.R., Khin E., Lim A., Sahib N.E., Wu Y., Chothani S.P., Schafer S., Bay B.-H., Sinha R.A., Cook S.A., Yen P.M.
Published 2020

Caffeine stimulates hepatic lipid metabolism by the autophagy-lysosomal pathway in mice

by Sinha R.A., Farah B.L., Singh B.K., Siddique M.M., Li Y., Wu Y., Ilkayeva O.R., Gooding J., Ching J., Zhou J., Martinez L., Xie S., Bay B.-H., Summers S.A., Newgard C.B., Yen P.M.
Published 2020

Thyroid hormone receptor and ERR coordinately regulate mitochondrial fission, mitophagy, biogenesis, and function

by Singh B.K., Sinha R.A., Tripathi M., Mendoza A., Ohba K., Sy J.A.C., Xie S.Y., Zhou J., Ho J.P., Chang C.-Y., Wu Y., Giguère V., Bay B.-H., Vanacker J.-M., Ghosh S., Gauthier K., Hollenberg A.N., McDonnell D.P., Yen P.M.
Published 2019

Low-dose levothyroxine reduces intrahepatic lipid content in patients with type 2 diabetes mellitus and NAFLD

by Bruinstroop E., Dalan R., Cao Y., Bee Y.M., Chandran K., Cho L.W., Soh S.B., Teo E.K., Toh S.-A., Leow M.K.S., Sinha R.A., Sadananthan S.A., Michael N., Stapleton H.M., Leung C., Angus P.W., Patel S.K., Burrell L.M., Lim S.C., Sum C.F., Velan S.S., Yen P.M.
Published 2020