Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by vitamin B supplementation

Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by vitamin B supplementation

10.1038/cddis.2016.374

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Bibliographic Details
Main Authors:	Tripathi, M, Zhang, C.W, Singh, B.K, Sinha, R.A, Moe, K.T, Desilva, D.A, Yen, P.M
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	adenosine triphosphatase cathepsin D glucose lysosome associated membrane protein 2 mammalian target of rapamycin oxygen rapamycin sequestosome 1 vitamin B group cyanocobalamin folic acid MAP1LC3 protein, mouse microtubule associated protein Sqstm1 protein, mouse target of rapamycin kinase animal cell animal experiment animal model Article astrocyte culture autophagy controlled study endoplasmic reticulum stress human human cell hyperhomocysteinemia in vitro study male mouse mouse model mTOR signaling nonhuman oxidative stress priority journal reperfusion unfolded protein response vitamin supplementation animal astrocyte biological model C57BL mouse cell culture cell survival deficiency diet dietary supplement drug effects lysosome metabolism pathology reperfusion injury tumor cell line Animals Astrocytes Autophagy Cell Line, Tumor Cell Survival Cells, Cultured Diet Dietary Supplements Endoplasmic Reticulum Stress Folic Acid Glucose Humans Hyperhomocysteinemia Lysosomes Male Mice Mice, Inbred C57BL Microtubule-Associated Proteins Models, Biological Oxidative Stress Oxygen Reperfusion Injury Sequestosome-1 Protein TOR Serine-Threonine Kinases Vitamin B 12
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/182518
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Institution:	National University of Singapore

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https://scholarbank.nus.edu.sg/handle/10635/182518