Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by vitamin B supplementation

• المؤلفون الرئيسيون: Tripathi, M, Zhang, C.W, Singh, B.K, Sinha, R.A, Moe, K.T, Desilva, D.A, Yen, P.M
• مؤلفون آخرون: DUKE-NUS MEDICAL SCHOOL
• التنسيق: مقال
• منشور في: Nature Publishing Group 2020
• الموضوعات: adenosine triphosphatase; cathepsin D; glucose; lysosome associated membrane protein 2; mammalian target of rapamycin; oxygen; rapamycin; sequestosome 1; vitamin B group; cyanocobalamin; folic acid; MAP1LC3 protein, mouse; microtubule associated protein; Sqstm1 protein, mouse; target of rapamycin kinase; animal cell; animal experiment; animal model; Article; astrocyte culture; autophagy; controlled study; endoplasmic reticulum stress; human; human cell; hyperhomocysteinemia; in vitro study; male; mouse; mouse model; mTOR signaling; nonhuman; oxidative stress; priority journal; reperfusion; unfolded protein response; vitamin supplementation; animal; astrocyte; biological model; C57BL mouse; cell culture; cell survival; deficiency; diet; dietary supplement; drug effects; lysosome; metabolism; pathology; reperfusion injury; tumor cell line; Animals; Astrocytes; Autophagy; Cell Line, Tumor; Cell Survival; Cells, Cultured; Diet; Dietary Supplements; Endoplasmic Reticulum Stress; Folic Acid; Glucose; Humans; Hyperhomocysteinemia; Lysosomes; Male; Mice; Mice, Inbred C57BL; Microtubule-Associated Proteins; Models, Biological; Oxidative Stress; Oxygen; Reperfusion Injury; Sequestosome-1 Protein; TOR Serine-Threonine Kinases; Vitamin B 12
• الوصول للمادة أونلاين: https://scholarbank.nus.edu.sg/handle/10635/182518

10.1038/cddis.2016.374