Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by vitamin B supplementation

10.1038/cddis.2016.374

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Main Authors:	Tripathi, M, Zhang, C.W, Singh, B.K, Sinha, R.A, Moe, K.T, Desilva, D.A, Yen, P.M
Other Authors:	DUKE-NUS MEDICAL SCHOOL
Format:	Article
Published:	Nature Publishing Group 2020
Subjects:	adenosine triphosphatase cathepsin D glucose lysosome associated membrane protein 2 mammalian target of rapamycin oxygen rapamycin sequestosome 1 vitamin B group cyanocobalamin folic acid MAP1LC3 protein, mouse microtubule associated protein Sqstm1 protein, mouse target of rapamycin kinase animal cell animal experiment animal model Article astrocyte culture autophagy controlled study endoplasmic reticulum stress human human cell hyperhomocysteinemia in vitro study male mouse mouse model mTOR signaling nonhuman oxidative stress priority journal reperfusion unfolded protein response vitamin supplementation animal astrocyte biological model C57BL mouse cell culture cell survival deficiency diet dietary supplement drug effects lysosome metabolism pathology reperfusion injury tumor cell line Animals Astrocytes Autophagy Cell Line, Tumor Cell Survival Cells, Cultured Diet Dietary Supplements Endoplasmic Reticulum Stress Folic Acid Glucose Humans Hyperhomocysteinemia Lysosomes Male Mice Mice, Inbred C57BL Microtubule-Associated Proteins Models, Biological Oxidative Stress Oxygen Reperfusion Injury Sequestosome-1 Protein TOR Serine-Threonine Kinases Vitamin B 12
Online Access:	https://scholarbank.nus.edu.sg/handle/10635/182518
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Institution:	National University of Singapore

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spelling	sg-nus-scholar.10635-1825182024-11-15T11:17:21Z Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by vitamin B supplementation Tripathi, M Zhang, C.W Singh, B.K Sinha, R.A Moe, K.T Desilva, D.A Yen, P.M DUKE-NUS MEDICAL SCHOOL adenosine triphosphatase cathepsin D glucose lysosome associated membrane protein 2 mammalian target of rapamycin oxygen rapamycin sequestosome 1 vitamin B group cyanocobalamin folic acid MAP1LC3 protein, mouse microtubule associated protein sequestosome 1 Sqstm1 protein, mouse target of rapamycin kinase animal cell animal experiment animal model Article astrocyte culture autophagy controlled study endoplasmic reticulum stress human human cell hyperhomocysteinemia in vitro study male mouse mouse model mTOR signaling nonhuman oxidative stress priority journal reperfusion unfolded protein response vitamin supplementation animal astrocyte autophagy biological model C57BL mouse cell culture cell survival deficiency diet dietary supplement drug effects endoplasmic reticulum stress hyperhomocysteinemia lysosome metabolism pathology reperfusion injury tumor cell line Animals Astrocytes Autophagy Cell Line, Tumor Cell Survival Cells, Cultured Diet Dietary Supplements Endoplasmic Reticulum Stress Folic Acid Glucose Humans Hyperhomocysteinemia Lysosomes Male Mice Mice, Inbred C57BL Microtubule-Associated Proteins Models, Biological Oxidative Stress Oxygen Reperfusion Injury Sequestosome-1 Protein TOR Serine-Threonine Kinases Vitamin B 12 10.1038/cddis.2016.374 Cell Death and Disease 7 12 e2513 2020-10-31T11:43:59Z 2020-10-31T11:43:59Z 2016 Article Tripathi, M, Zhang, C.W, Singh, B.K, Sinha, R.A, Moe, K.T, Desilva, D.A, Yen, P.M (2016). Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by vitamin B supplementation. Cell Death and Disease 7 (12) : e2513. ScholarBank@NUS Repository. https://doi.org/10.1038/cddis.2016.374 2041-4889 https://scholarbank.nus.edu.sg/handle/10635/182518 Attribution 4.0 International http://creativecommons.org/licenses/by/4.0/ Nature Publishing Group Unpaywall 20201031
institution	National University of Singapore
building	NUS Library
continent	Asia
country	Singapore Singapore
content_provider	NUS Library
collection	ScholarBank@NUS
topic	adenosine triphosphatase cathepsin D glucose lysosome associated membrane protein 2 mammalian target of rapamycin oxygen rapamycin sequestosome 1 vitamin B group cyanocobalamin folic acid MAP1LC3 protein, mouse microtubule associated protein sequestosome 1 Sqstm1 protein, mouse target of rapamycin kinase animal cell animal experiment animal model Article astrocyte culture autophagy controlled study endoplasmic reticulum stress human human cell hyperhomocysteinemia in vitro study male mouse mouse model mTOR signaling nonhuman oxidative stress priority journal reperfusion unfolded protein response vitamin supplementation animal astrocyte autophagy biological model C57BL mouse cell culture cell survival deficiency diet dietary supplement drug effects endoplasmic reticulum stress hyperhomocysteinemia lysosome metabolism pathology reperfusion injury tumor cell line Animals Astrocytes Autophagy Cell Line, Tumor Cell Survival Cells, Cultured Diet Dietary Supplements Endoplasmic Reticulum Stress Folic Acid Glucose Humans Hyperhomocysteinemia Lysosomes Male Mice Mice, Inbred C57BL Microtubule-Associated Proteins Models, Biological Oxidative Stress Oxygen Reperfusion Injury Sequestosome-1 Protein TOR Serine-Threonine Kinases Vitamin B 12
spellingShingle	adenosine triphosphatase cathepsin D glucose lysosome associated membrane protein 2 mammalian target of rapamycin oxygen rapamycin sequestosome 1 vitamin B group cyanocobalamin folic acid MAP1LC3 protein, mouse microtubule associated protein sequestosome 1 Sqstm1 protein, mouse target of rapamycin kinase animal cell animal experiment animal model Article astrocyte culture autophagy controlled study endoplasmic reticulum stress human human cell hyperhomocysteinemia in vitro study male mouse mouse model mTOR signaling nonhuman oxidative stress priority journal reperfusion unfolded protein response vitamin supplementation animal astrocyte autophagy biological model C57BL mouse cell culture cell survival deficiency diet dietary supplement drug effects endoplasmic reticulum stress hyperhomocysteinemia lysosome metabolism pathology reperfusion injury tumor cell line Animals Astrocytes Autophagy Cell Line, Tumor Cell Survival Cells, Cultured Diet Dietary Supplements Endoplasmic Reticulum Stress Folic Acid Glucose Humans Hyperhomocysteinemia Lysosomes Male Mice Mice, Inbred C57BL Microtubule-Associated Proteins Models, Biological Oxidative Stress Oxygen Reperfusion Injury Sequestosome-1 Protein TOR Serine-Threonine Kinases Vitamin B 12 Tripathi, M Zhang, C.W Singh, B.K Sinha, R.A Moe, K.T Desilva, D.A Yen, P.M Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by vitamin B supplementation
description	10.1038/cddis.2016.374
author2	DUKE-NUS MEDICAL SCHOOL
author_facet	DUKE-NUS MEDICAL SCHOOL Tripathi, M Zhang, C.W Singh, B.K Sinha, R.A Moe, K.T Desilva, D.A Yen, P.M
format	Article
author	Tripathi, M Zhang, C.W Singh, B.K Sinha, R.A Moe, K.T Desilva, D.A Yen, P.M
author_sort	Tripathi, M
title	Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by vitamin B supplementation
title_short	Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by vitamin B supplementation
title_full	Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by vitamin B supplementation
title_fullStr	Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by vitamin B supplementation
title_full_unstemmed	Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by vitamin B supplementation
title_sort	hyperhomocysteinemia causes er stress and impaired autophagy that is reversed by vitamin b supplementation
publisher	Nature Publishing Group
publishDate	2020
url	https://scholarbank.nus.edu.sg/handle/10635/182518
_version_	1821210938848575488

Hyperhomocysteinemia causes ER stress and impaired autophagy that is reversed by vitamin B supplementation

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