A loss-of-function genetic screening reveals synergistic targeting of AKT/mTOR and WTN/β-catenin pathways for treatment of AML with high PRL-3 phosphatase

by Zhou, J, Toh, S.H.-M, Chan, Z.-L, Quah, J.Y, Chooi, J.-Y, Tan, T.Z, Chong, P.S.Y, Zeng, Q, Chng, W.-J
Published 2020

Inhibition of LIN28B impairs leukemia cell growth and metabolism in acute myeloid leukemia

by Zhou, J, Bi, C, Ching, Y.Q, Chooi, J.-Y, Lu, X, Quah, J.Y, Toh, S.H.-M, Chan, Z.-L, Tan, T.Z, Chong, P.S, Chng, W.-J
Published 2020

ASLAN003, a potent dihydroorotate dehydrogenase inhibitor for differentiation of acute myeloid leukemia

by Zhou, J., Quah, J.Y., Ng, Y., Chooi, J.-Y., Toh, S.H.-M., Lin, B., Tan, T.Z., Hosoi, H., Osato, M., Seet, Q., Lisa Ooi, A.G., Lindmark, B., McHale, M., Chng, W.-J.
Published 2021

Super enhancer-mediated upregulation of HJURP promotes growth and survival of t(4;14)-positive multiple myeloma

by Jia, Yunlu, Zhou, Jianbiao, Tan, Tze King, Chung, Tae-Hoon, Chen, Yongxia, Chooi, Jing-Yuan, Sanda, Takaomi, Fullwood, Melissa Jane, Xiong, Sinan, Toh, Sabrina H. M., Balan, Kalpnaa, Wong, Regina W. J., Lim, Julia S. L., Zhang, Enfan, Cai, Zhen, Shen, Peng, Chng, Wee Joo
Published 2022