Inhibition of LIN28B impairs leukemia cell growth and metabolism in acute myeloid leukemia

• Main Authors: Zhou, J, Bi, C, Ching, Y.Q, Chooi, J.-Y, Lu, X, Quah, J.Y, Toh, S.H.-M, Chan, Z.-L, Tan, T.Z, Chong, P.S, Chng, W.-J
• Other Authors: CANCER SCIENCE INSTITUTE OF SINGAPORE
• Format: Article
• Published: 2020
• Subjects: let 7a; LIN28B protein; microRNA; stem cell factor; unclassified drug; LIN28B protein, human; mirnlet7 microRNA, human; RNA binding protein; small interfering RNA; acute myeloid leukemia; animal experiment; animal model; animal tissue; Article; bioinformatics; cancer inhibition; carcinogenicity; cell cycle arrest; cell metabolism; cell proliferation; colony formation; controlled study; female; G2 phase cell cycle checkpoint; gene; gene function; gene overexpression; gene silencing; gene targeting; genetic association; hematopoiesis; human; human cell; IGF2BP1 gene; in vivo study; KDM4A gene; leukemia cell; leukemogenesis; LIN28B gene; microarray analysis; mouse; nonhuman; oncogene; PSAT1 gene; signal transduction; tumor xenograft; animal; cell cycle checkpoint; gene expression regulation; genetics; metabolism; nonobese diabetic mouse; pathology; RNA interference; SCID mouse; tumor cell line; Animals; Cell Cycle Checkpoints; Cell Line, Tumor; Cell Proliferation; Female; Gene Expression Regulation, Leukemic; Humans; Leukemia, Myeloid, Acute; Mice; Mice, Inbred NOD; Mice, SCID; MicroRNAs; RNA Interference; RNA, Small Interfering; RNA-Binding Proteins
• Online Access: https://scholarbank.nus.edu.sg/handle/10635/173782
• Institution: National University of Singapore

10.1186/s13045-017-0507-y