Anti–Peri-implantitis Bacteria’s Ability of Robusta Green Coffee Bean (Coffea Canephora) Ethanol Extract: An In Silico and In Vitro Study

Anti–Peri-implantitis Bacteria’s Ability of Robusta Green Coffee Bean (Coffea Canephora) Ethanol Extract: An In Silico and In Vitro Study

Introduction Treatment of dentofacial malocclusion with mini orthodontic implants may be promising but it is frequently related to bacterial infection–induced production of inflammatory mediators that affect mini-implant osseointegration. For robusta green coffee bean (RGCB; Coffea canephora), etha...

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Main Authors: Alexander P. Nugraha, -, I G. A. W. Ardani, -, Ratri Maya Sitalaksmi, -, Nastiti F. Ramadhani, -, Desi Rachmayanti, -, Dina Kumala, -, Viol D. Kharisma, -, Desintya Rahmadani, -, Martining S. Puspitaningrum, -, Yuniar Rizqianti, -, Muhammad Dimas Aditya Ari, -, Albertus P. Nugraha, -, Tengku N. E. B. T. A. Noor, -, Muhammad Luthfi, -
Format: Article PeerReviewed
Language:English
English
English
Published: EJD (Thieme Medical and Scientifific) 2021
Subjects:
R Medicine
RK Dentistry
Online Access:https://repository.unair.ac.id/123782/2/A5.pdf
https://repository.unair.ac.id/123782/3/T5.pdf
https://repository.unair.ac.id/123782/1/5.pdf
https://repository.unair.ac.id/123782/
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Institution: Universitas Airlangga
Language: English
English
English
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Summary:Introduction Treatment of dentofacial malocclusion with mini orthodontic implants may be promising but it is frequently related to bacterial infection–induced production of inflammatory mediators that affect mini-implant osseointegration. For robusta green coffee bean (RGCB; Coffea canephora), ethanol extract may be beneficial as antioxidant, anti-inflammatory, induce osteogenic, and growth factor protein for anti–peri-implantitis. Objective This study was aimed to investigate RGCBE extract as antioxidant and anti–peri-implantitis bacteria through in vitro study and its potential as antioxidant, antibacterial, anti-inflammatory, antibone resorption, and proosteogenic through in silico study. Materials and Methods Absorption, distribution, metabolism, excretion and toxicity prediction, molecular docking simulation, and visualization of chlorogenic acid (CGA) and coumaric acid (CA) as anti-inflammatory, antioxidant, and antibacterial were investigated in silico. Inhibition zone by diffusion method, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) of RGCBE extract against Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Fusobacterium nucleatum (Fn), and Prevotella intermedia (Pi) were done.

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