Anti–Peri-implantitis Bacteria’s Ability of Robusta Green Coffee Bean (Coffea Canephora) Ethanol Extract: An In Silico and In Vitro Study
Introduction Treatment of dentofacial malocclusion with mini orthodontic implants may be promising but it is frequently related to bacterial infection–induced production of inflammatory mediators that affect mini-implant osseointegration. For robusta green coffee bean (RGCB; Coffea canephora), etha...
Saved in:
Main Authors: | , , , , , , , , , , , , , |
---|---|
Format: | Article PeerReviewed |
Language: | English English English |
Published: |
EJD (Thieme Medical and Scientifific)
2021
|
Subjects: | |
Online Access: | https://repository.unair.ac.id/123782/2/A5.pdf https://repository.unair.ac.id/123782/3/T5.pdf https://repository.unair.ac.id/123782/1/5.pdf https://repository.unair.ac.id/123782/ |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Institution: | Universitas Airlangga |
Language: | English English English |
id |
id-langga.123782 |
---|---|
record_format |
dspace |
spelling |
id-langga.1237822023-04-16T13:10:17Z https://repository.unair.ac.id/123782/ Anti–Peri-implantitis Bacteria’s Ability of Robusta Green Coffee Bean (Coffea Canephora) Ethanol Extract: An In Silico and In Vitro Study Alexander P. Nugraha, - I G. A. W. Ardani, - Ratri Maya Sitalaksmi, - Nastiti F. Ramadhani, - Desi Rachmayanti, - Dina Kumala, - Viol D. Kharisma, - Desintya Rahmadani, - Martining S. Puspitaningrum, - Yuniar Rizqianti, - Muhammad Dimas Aditya Ari, - Albertus P. Nugraha, - Tengku N. E. B. T. A. Noor, - Muhammad Luthfi, - R Medicine RK Dentistry Introduction Treatment of dentofacial malocclusion with mini orthodontic implants may be promising but it is frequently related to bacterial infection–induced production of inflammatory mediators that affect mini-implant osseointegration. For robusta green coffee bean (RGCB; Coffea canephora), ethanol extract may be beneficial as antioxidant, anti-inflammatory, induce osteogenic, and growth factor protein for anti–peri-implantitis. Objective This study was aimed to investigate RGCBE extract as antioxidant and anti–peri-implantitis bacteria through in vitro study and its potential as antioxidant, antibacterial, anti-inflammatory, antibone resorption, and proosteogenic through in silico study. Materials and Methods Absorption, distribution, metabolism, excretion and toxicity prediction, molecular docking simulation, and visualization of chlorogenic acid (CGA) and coumaric acid (CA) as anti-inflammatory, antioxidant, and antibacterial were investigated in silico. Inhibition zone by diffusion method, minimum inhibitory concentration (MIC), and minimum bactericidal concentration (MBC) of RGCBE extract against Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg), Fusobacterium nucleatum (Fn), and Prevotella intermedia (Pi) were done. EJD (Thieme Medical and Scientifific) 2021 Article PeerReviewed text en https://repository.unair.ac.id/123782/2/A5.pdf text en https://repository.unair.ac.id/123782/3/T5.pdf text en https://repository.unair.ac.id/123782/1/5.pdf Alexander P. Nugraha, - and I G. A. W. Ardani, - and Ratri Maya Sitalaksmi, - and Nastiti F. Ramadhani, - and Desi Rachmayanti, - and Dina Kumala, - and Viol D. Kharisma, - and Desintya Rahmadani, - and Martining S. Puspitaningrum, - and Yuniar Rizqianti, - and Muhammad Dimas Aditya Ari, - and Albertus P. Nugraha, - and Tengku N. E. B. T. A. Noor, - and Muhammad Luthfi, - (2021) Anti–Peri-implantitis Bacteria’s Ability of Robusta Green Coffee Bean (Coffea Canephora) Ethanol Extract: An In Silico and In Vitro Study. European Journal of Dentistry, 16. ISSN 1305-7456 10.1055/s-0042-1750803 |
institution |
Universitas Airlangga |
building |
Universitas Airlangga Library |
continent |
Asia |
country |
Indonesia Indonesia |
content_provider |
Universitas Airlangga Library |
collection |
UNAIR Repository |
language |
English English English |
topic |
R Medicine RK Dentistry |
spellingShingle |
R Medicine RK Dentistry Alexander P. Nugraha, - I G. A. W. Ardani, - Ratri Maya Sitalaksmi, - Nastiti F. Ramadhani, - Desi Rachmayanti, - Dina Kumala, - Viol D. Kharisma, - Desintya Rahmadani, - Martining S. Puspitaningrum, - Yuniar Rizqianti, - Muhammad Dimas Aditya Ari, - Albertus P. Nugraha, - Tengku N. E. B. T. A. Noor, - Muhammad Luthfi, - Anti–Peri-implantitis Bacteria’s Ability of Robusta Green Coffee Bean (Coffea Canephora) Ethanol Extract: An In Silico and In Vitro Study |
description |
Introduction Treatment of dentofacial malocclusion with mini orthodontic implants may be promising but it is frequently related to bacterial infection–induced production
of inflammatory mediators that affect mini-implant osseointegration. For robusta green coffee bean (RGCB; Coffea canephora), ethanol extract may be beneficial as
antioxidant, anti-inflammatory, induce osteogenic, and growth factor protein for anti–peri-implantitis.
Objective This study was aimed to investigate RGCBE extract as antioxidant and anti–peri-implantitis bacteria through in vitro study and its potential as antioxidant, antibacterial, anti-inflammatory, antibone resorption, and proosteogenic through in silico study.
Materials and Methods Absorption, distribution, metabolism, excretion and toxicity prediction, molecular docking simulation, and visualization of chlorogenic acid (CGA)
and coumaric acid (CA) as anti-inflammatory, antioxidant, and antibacterial were investigated in silico. Inhibition zone by diffusion method, minimum inhibitory
concentration (MIC), and minimum bactericidal concentration (MBC) of RGCBE extract against Aggregatibacter actinomycetemcomitans (Aa), Porphyromonas gingivalis (Pg),
Fusobacterium nucleatum (Fn), and Prevotella intermedia (Pi) were done. |
format |
Article PeerReviewed |
author |
Alexander P. Nugraha, - I G. A. W. Ardani, - Ratri Maya Sitalaksmi, - Nastiti F. Ramadhani, - Desi Rachmayanti, - Dina Kumala, - Viol D. Kharisma, - Desintya Rahmadani, - Martining S. Puspitaningrum, - Yuniar Rizqianti, - Muhammad Dimas Aditya Ari, - Albertus P. Nugraha, - Tengku N. E. B. T. A. Noor, - Muhammad Luthfi, - |
author_facet |
Alexander P. Nugraha, - I G. A. W. Ardani, - Ratri Maya Sitalaksmi, - Nastiti F. Ramadhani, - Desi Rachmayanti, - Dina Kumala, - Viol D. Kharisma, - Desintya Rahmadani, - Martining S. Puspitaningrum, - Yuniar Rizqianti, - Muhammad Dimas Aditya Ari, - Albertus P. Nugraha, - Tengku N. E. B. T. A. Noor, - Muhammad Luthfi, - |
author_sort |
Alexander P. Nugraha, - |
title |
Anti–Peri-implantitis Bacteria’s Ability of Robusta Green Coffee Bean (Coffea Canephora) Ethanol Extract: An In Silico and In Vitro Study |
title_short |
Anti–Peri-implantitis Bacteria’s Ability of Robusta Green Coffee Bean (Coffea Canephora) Ethanol Extract: An In Silico and In Vitro Study |
title_full |
Anti–Peri-implantitis Bacteria’s Ability of Robusta Green Coffee Bean (Coffea Canephora) Ethanol Extract: An In Silico and In Vitro Study |
title_fullStr |
Anti–Peri-implantitis Bacteria’s Ability of Robusta Green Coffee Bean (Coffea Canephora) Ethanol Extract: An In Silico and In Vitro Study |
title_full_unstemmed |
Anti–Peri-implantitis Bacteria’s Ability of Robusta Green Coffee Bean (Coffea Canephora) Ethanol Extract: An In Silico and In Vitro Study |
title_sort |
anti–peri-implantitis bacteria’s ability of robusta green coffee bean (coffea canephora) ethanol extract: an in silico and in vitro study |
publisher |
EJD (Thieme Medical and Scientifific) |
publishDate |
2021 |
url |
https://repository.unair.ac.id/123782/2/A5.pdf https://repository.unair.ac.id/123782/3/T5.pdf https://repository.unair.ac.id/123782/1/5.pdf https://repository.unair.ac.id/123782/ |
_version_ |
1764209120445988864 |