Amphiregulin induces CCN2 and fibronectin expression by TGF-β through EGFR-dependent pathway in lung epithelial cells

• Main Authors: Cheng, Wun‑Hao, Kao, Shih‑Ya, Chen, Chia‑Ling, Yuliani, Fara Silvia, Lin, Lee‑Yuan, Lin, Chien‑Huang, Chen, Bing‑Chang
• Format: Article PeerReviewed
• Language: English
• Published: Springer 2022
• Subjects: Clinical Sciences
• Online Access: https://repository.ugm.ac.id/278652/1/Yuliani_KKMK.pdf; https://repository.ugm.ac.id/278652/; https://respiratory-research.biomedcentral.com/articles/10.1186/s12931-022-02285-2; https://doi.org/10.1186/s12931-022-02285-2
• Institution: Universitas Gadjah Mada

Background: Airway fibrosis is one of the pathological characteristics of severe asthma. Transforming growth factor (TGF)‑β has been known to promote epithelial‑mesenchymal transition formation and to play a role in the progres‑ sion of tissue fibrosis. Cellular communication network factor 2 (CCN...