Marine sponge cyclic peptide theonellamide A disrupts lipid bilayer integrity without forming distinct membrane pores

• Main Authors: Espiritu, Rafael Atillo, Cornelio, Kimberly, Kinoshita, Masanao, Matsumori, Nobuaki, Murata, Michio, Nishimura, Shinichi, Kakeya, Hideaki, Yoshida, Minoru, Matsunaga, Shigeki
• Format: text
• Published: Animo Repository 2016
• Subjects: Oligopeptides; Peptides; Sponges; Liposomes; Bilayer lipid membranes; Chemistry
• Online Access: https://animorepository.dlsu.edu.ph/faculty_research/2962
• Institution: De La Salle University

Theonellamides (TNMs) are antifungal and cytotoxic bicyclic dodecapeptides derived from the marine sponge Theonella sp. These peptides specifically bind to 3β-hydroxysterols, resulting in 1,3-β-d-glucan overproduction and membrane damage in yeasts. The inclusion of cholesterol or ergosterol in phosp...