Structure of a mutagen from roasted seeds of Moringa oleifera

Structure of a mutagen from roasted seeds of Moringa oleifera

A mutagenic compound was isolated from roasted seeds of Moringa oleifera Lam. Its structure has been elucidated by spectral analysis as 4(α-L-rhamnosyloxy)phenylacetonitrile. The results of the Micronucleus Test, an in vivo method, showed that the number of micronucleated polychromatic erythrocytes...

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Bibliographic Details
Main Authors: Villasenor, Irene M, Finch, Paul, Lim-Sylianco, Clara, Dayrit, Fabian M
Format: text
Published: Archīum Ateneo 1989
Subjects:
erythrocytes
dimethyl sulfoxide
micronucleus tests
moringa oleifera
mutagens
seeds
solvents
spectrum analysis
tetracycline
positive control
Biochemistry
Chemistry
Online Access:https://archium.ateneo.edu/chemistry-faculty-pubs/114
https://academic.oup.com/carcin/article-abstract/10/6/1085/404083
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Institution: Ateneo De Manila University
Description
Summary:A mutagenic compound was isolated from roasted seeds of Moringa oleifera Lam. Its structure has been elucidated by spectral analysis as 4(α-L-rhamnosyloxy)phenylacetonitrile. The results of the Micronucleus Test, an in vivo method, showed that the number of micronucleated polychromatic erythrocytes (PCE)/1000 PCE for this compound is higher than that of the solvent control, dimethylsulfoxide, and approximates that of the positive control, tetracycline. This indicates that 4(α-L-rhamnosyloxy)phenylacetonitrile is a genotoxic compound.

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