Structure of a mutagen from roasted seeds of Moringa oleifera
A mutagenic compound was isolated from roasted seeds of Moringa oleifera Lam. Its structure has been elucidated by spectral analysis as 4(α-L-rhamnosyloxy)phenylacetonitrile. The results of the Micronucleus Test, an in vivo method, showed that the number of micronucleated polychromatic erythrocytes...
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Archīum Ateneo
1989
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ph-ateneo-arc.chemistry-faculty-pubs-11132020-07-27T08:40:41Z Structure of a mutagen from roasted seeds of Moringa oleifera Villasenor, Irene M Finch, Paul Lim-Sylianco, Clara Dayrit, Fabian M A mutagenic compound was isolated from roasted seeds of Moringa oleifera Lam. Its structure has been elucidated by spectral analysis as 4(α-L-rhamnosyloxy)phenylacetonitrile. The results of the Micronucleus Test, an in vivo method, showed that the number of micronucleated polychromatic erythrocytes (PCE)/1000 PCE for this compound is higher than that of the solvent control, dimethylsulfoxide, and approximates that of the positive control, tetracycline. This indicates that 4(α-L-rhamnosyloxy)phenylacetonitrile is a genotoxic compound. 1989-01-01T08:00:00Z text https://archium.ateneo.edu/chemistry-faculty-pubs/114 https://academic.oup.com/carcin/article-abstract/10/6/1085/404083 Chemistry Faculty Publications Archīum Ateneo erythrocytes dimethyl sulfoxide micronucleus tests moringa oleifera mutagens seeds solvents spectrum analysis tetracycline positive control Biochemistry Chemistry |
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erythrocytes dimethyl sulfoxide micronucleus tests moringa oleifera mutagens seeds solvents spectrum analysis tetracycline positive control Biochemistry Chemistry |
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erythrocytes dimethyl sulfoxide micronucleus tests moringa oleifera mutagens seeds solvents spectrum analysis tetracycline positive control Biochemistry Chemistry Villasenor, Irene M Finch, Paul Lim-Sylianco, Clara Dayrit, Fabian M Structure of a mutagen from roasted seeds of Moringa oleifera |
| description |
A mutagenic compound was isolated from roasted seeds of Moringa oleifera Lam. Its structure has been elucidated by spectral analysis as 4(α-L-rhamnosyloxy)phenylacetonitrile. The results of the Micronucleus Test, an in vivo method, showed that the number of micronucleated polychromatic erythrocytes (PCE)/1000 PCE for this compound is higher than that of the solvent control, dimethylsulfoxide, and approximates that of the positive control, tetracycline. This indicates that 4(α-L-rhamnosyloxy)phenylacetonitrile is a genotoxic compound. |
| format |
text |
| author |
Villasenor, Irene M Finch, Paul Lim-Sylianco, Clara Dayrit, Fabian M |
| author_facet |
Villasenor, Irene M Finch, Paul Lim-Sylianco, Clara Dayrit, Fabian M |
| author_sort |
Villasenor, Irene M |
| title |
Structure of a mutagen from roasted seeds of Moringa oleifera |
| title_short |
Structure of a mutagen from roasted seeds of Moringa oleifera |
| title_full |
Structure of a mutagen from roasted seeds of Moringa oleifera |
| title_fullStr |
Structure of a mutagen from roasted seeds of Moringa oleifera |
| title_full_unstemmed |
Structure of a mutagen from roasted seeds of Moringa oleifera |
| title_sort |
structure of a mutagen from roasted seeds of moringa oleifera |
| publisher |
Archīum Ateneo |
| publishDate |
1989 |
| url |
https://archium.ateneo.edu/chemistry-faculty-pubs/114 https://academic.oup.com/carcin/article-abstract/10/6/1085/404083 |
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