Inhibition of the human respiratory syncytial virus small hydrophobic protein and structural variations in a bicelle environment

• Main Authors: Li, Yan, To, Janet, Verdià-Baguena, Carmina, Dossena, Silvia, Surya, Wahyu, Huang, Mei, Paulmichi, Markus, Liu, Ding Xiang, Aguilella, Vicente M., Torres, Jaume
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/100387; http://hdl.handle.net/10220/25717
• Institution: Nanyang Technological University

The small hydrophobic (SH) protein is a 64-amino-acid polypeptide encoded by the human respiratory syncytial virus (hRSV). SH protein has a single α-helical transmembrane (TM) domain that forms pentameric ion channels. Herein, we report the first inhibitor of the SH protein channel, pyronin B, and w...