Identification of LasR ligands through a virtual screening approach

• Main Authors: Skovstrup, Søren, Le Quement, Sebastian Thordal, Hansen, Thomas, Jakobsen, Tim Holm, Harmsen, Morten, Tolker-Nielsen, Tim, Nielsen, Thomas E., Givskov, Michael, Taboureau, Olivier
• 格式: Article
• 語言: English
• 出版: 2014
• 主題: DRNTU::Science::Medicine::Biomedical engineering
• 在線閱讀: https://hdl.handle.net/10356/101701; http://hdl.handle.net/10220/19785

With the widespread occurrence of bacterial resistance to antibiotics, the development of new strategies beyond conventional treatments is a pursuit taken by public health institutions worldwide. LasR, a transcription factor that controls quorum sensing in Pseudomonas aeruginosa, has emerged as an a...