Syn-lethality : an integrative knowledge base of synthetic lethality towards discovery of selective anticancer therapies

• Main Authors: Li, Xue-juan, Mishra, Shital K., Wu, Min, Zhang, Fan, Zheng, Jie
• Other Authors: School of Computer Engineering
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Medicine::Biomedical engineering
• Online Access: https://hdl.handle.net/10356/101761; http://hdl.handle.net/10220/19741
• Institution: Nanyang Technological University

Synthetic lethality (SL) is a novel strategy for anticancer therapies, whereby mutations of two genes will kill a cell but mutation of a single gene will not. Therefore, a cancer-specific mutation combined with a drug-induced mutation, if they have SL interactions, will selectively kill cancer cells...