Sox transcription factors require selective interactions with Oct4 and specific transactivation functions to mediate reprogramming

• المؤلفون الرئيسيون: Aksoy, Irene, Jauch, Ralf, Eras, Volker, Chng, Wen-bin Alfred, Chen, Jiaxuan, Divakar, Ushashree, Ng, Calista Keow Leng, Kolatkar, Prasanna R., Stanton, Lawrence W.
• مؤلفون آخرون: School of Biological Sciences
• التنسيق: مقال
• اللغة: English
• منشور في: 2014
• الموضوعات: DRNTU::Science::Biological sciences
• الوصول للمادة أونلاين: https://hdl.handle.net/10356/102574; http://hdl.handle.net/10220/19110

The unique ability of Sox2 to cooperate with Oct4 at selective binding sites in the genome is critical for reprogramming somatic cells into induced pluripotent stem cells (iPSCs). We have recently demonstrated that Sox17 can be converted into a reprogramming factor by alteration of a single amino ac...