Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3
Phen-DC3 is a highly promising compound that specifically targets G-quadruplexes, with potent biological effects observed in vivo. We used NMR spectroscopy to solve the structure of the complex formed between Phen-DC3 and an intramolecular G-quadruplex derived from the c-myc promoter. Structural inf...
Saved in:
| Main Authors: | , , , , |
|---|---|
| Other Authors: | |
| Format: | Article |
| Language: | English |
| Published: |
2014
|
| Subjects: | |
| Online Access: | https://hdl.handle.net/10356/102946 http://hdl.handle.net/10220/19192 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| Institution: | Nanyang Technological University |
| Language: | English |
| id |
sg-ntu-dr.10356-102946 |
|---|---|
| record_format |
dspace |
| spelling |
sg-ntu-dr.10356-1029462020-03-07T12:37:12Z Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3 Chung, Wan Jun Heddi, Brahim Hamon, Florian Teulade-Fichou, Marie-Paule Phan, Anh Tuân School of Physical and Mathematical Sciences DRNTU::Science::Chemistry Phen-DC3 is a highly promising compound that specifically targets G-quadruplexes, with potent biological effects observed in vivo. We used NMR spectroscopy to solve the structure of the complex formed between Phen-DC3 and an intramolecular G-quadruplex derived from the c-myc promoter. Structural information revealed that Phen-DC3 interacts with the quadruplex through extensive π-stacking with guanine bases of the top G-tetrad. On the basis of our structure, modifications are proposed for the development of this compound for selective targeting of a specific G-quadruplex conformation. 2014-04-09T06:16:49Z 2019-12-06T21:02:36Z 2014-04-09T06:16:49Z 2019-12-06T21:02:36Z 2014 2014 Journal Article Chung, W. J., Heddi, B., Hamon, F., Teulade-Fichou, M.-P., & Phan, A. T. (2014). Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3. Angewandte Chemie International Edition, 53(4), 999-1002. 1433-7851 https://hdl.handle.net/10356/102946 http://hdl.handle.net/10220/19192 10.1002/anie.201308063 en Angewandte chemie international edition © 2014 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
| institution |
Nanyang Technological University |
| building |
NTU Library |
| country |
Singapore |
| collection |
DR-NTU |
| language |
English |
| topic |
DRNTU::Science::Chemistry |
| spellingShingle |
DRNTU::Science::Chemistry Chung, Wan Jun Heddi, Brahim Hamon, Florian Teulade-Fichou, Marie-Paule Phan, Anh Tuân Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3 |
| description |
Phen-DC3 is a highly promising compound that specifically targets G-quadruplexes, with potent biological effects observed in vivo. We used NMR spectroscopy to solve the structure of the complex formed between Phen-DC3 and an intramolecular G-quadruplex derived from the c-myc promoter. Structural information revealed that Phen-DC3 interacts with the quadruplex through extensive π-stacking with guanine bases of the top G-tetrad. On the basis of our structure, modifications are proposed for the development of this compound for selective targeting of a specific G-quadruplex conformation. |
| author2 |
School of Physical and Mathematical Sciences |
| author_facet |
School of Physical and Mathematical Sciences Chung, Wan Jun Heddi, Brahim Hamon, Florian Teulade-Fichou, Marie-Paule Phan, Anh Tuân |
| format |
Article |
| author |
Chung, Wan Jun Heddi, Brahim Hamon, Florian Teulade-Fichou, Marie-Paule Phan, Anh Tuân |
| author_sort |
Chung, Wan Jun |
| title |
Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3 |
| title_short |
Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3 |
| title_full |
Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3 |
| title_fullStr |
Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3 |
| title_full_unstemmed |
Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3 |
| title_sort |
solution structure of a g-quadruplex bound to the bisquinolinium compound phen-dc3 |
| publishDate |
2014 |
| url |
https://hdl.handle.net/10356/102946 http://hdl.handle.net/10220/19192 |
| _version_ |
1681037001812344832 |