Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3

• Main Authors: Chung, Wan Jun, Heddi, Brahim, Hamon, Florian, Teulade-Fichou, Marie-Paule, Phan, Anh Tuân
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Chemistry
• Online Access: https://hdl.handle.net/10356/102946; http://hdl.handle.net/10220/19192
• Institution: Nanyang Technological University

Phen-DC3 is a highly promising compound that specifically targets G-quadruplexes, with potent biological effects observed in vivo. We used NMR spectroscopy to solve the structure of the complex formed between Phen-DC3 and an intramolecular G-quadruplex derived from the c-myc promoter. Structural inf...