Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3

Solution structure of a G-quadruplex bound to the bisquinolinium compound Phen-DC3

Phen-DC3 is a highly promising compound that specifically targets G-quadruplexes, with potent biological effects observed in vivo. We used NMR spectroscopy to solve the structure of the complex formed between Phen-DC3 and an intramolecular G-quadruplex derived from the c-myc promoter. Structural inf...

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Bibliographic Details
Main Authors: Chung, Wan Jun, Heddi, Brahim, Hamon, Florian, Teulade-Fichou, Marie-Paule, Phan, Anh Tuân
Other Authors: School of Physical and Mathematical Sciences
Format: Article
Language:English
Published: 2014
Subjects:
DRNTU::Science::Chemistry
Online Access:https://hdl.handle.net/10356/102946
http://hdl.handle.net/10220/19192
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Institution: Nanyang Technological University
Language: English

Internet

https://hdl.handle.net/10356/102946
http://hdl.handle.net/10220/19192

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