Extracellular DNA shields against aminoglycosides in pseudomonas aeruginosa biofilms

• Main Authors: Chiang, Wen-Chi, Nilsson, Martin, Jensen, Peter Østrup, Høiby, Niels, Nielsen, Thomas Eiland, Givskov, Michael, Tolker-Nielsen, Tim
• Other Authors: Singapore Centre for Environmental Life Sciences Engineering
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Bacteria
• Online Access: https://hdl.handle.net/10356/103038; http://hdl.handle.net/10220/25803
• Institution: Nanyang Technological University

Within recent years, it has been established that extracellular DNA is a key constituent of the matrix of microbial biofilms. In addition, it has recently been demonstrated that DNA binds positively charged antimicrobials such as aminoglycosides and antimicrobial peptides. In the present study, we p...