De Novo Generated Human Red Blood Cells in Humanized Mice Support Plasmodium falciparum Infection

• Main Authors: Amaladoss, Anburaj, Chen, Qingfeng, Liu, Min, Dummler, Sara K., Dao, Ming, Suresh, Subra, Chen, Jianzhu, Preiser, Peter R.
• Other Authors: Marinho, Claudio Romero Farias
• Format: Article
• Language: English
• Published: 2015
• Online Access: https://hdl.handle.net/10356/103060; http://hdl.handle.net/10220/38703
• Institution: Nanyang Technological University

Immunodeficient mouse–human chimeras provide a powerful approach to study host specific pathogens like Plasmodium (P.) falciparum that causes human malaria. Existing mouse models of P. falciparum infection require repeated injections of human red blood cells (RBCs). In addition, clodronate lipsomes...