Apolipoprotein CIII links islet insulin resistance to β-cell failure in diabetes

• Main Authors: Leibiger, Ingo B., Leibiger, Barbara, Moede, Tilo, Paschen, Meike, Dicker, Andrea, Abdulreda, Midhat H., Åvall, Karin, Ali, Yusuf, Daré, Elisabetta, Köhler, Martin, Ilegems, Erwin, Graham, Mark, Crooke, Rosanne M., Tay, Vanessa Shi Yun, Refai, Essam, Nilsson, Stefan K., Jacob, Stefan, Selander, Lars, Berggren, Per-Olof, Juntti-Berggren, Lisa
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2015
• Subjects: diabetes; apoCIII; insulin resistance; pancreatic islets
• Online Access: https://hdl.handle.net/10356/103306; http://hdl.handle.net/10220/25742
• Institution: Nanyang Technological University

Insulin resistance and β-cell failure are the major defects in type 2 diabetes mellitus. However, the molecular mechanisms linking these two defects remain unknown. Elevated levels of apolipoprotein CIII (apoCIII) are associated not only with insulin resistance but also with cardiovascular disorders...