The thrombin-derived host defense peptide GKY25 inhibits endotoxin-induced responses through Interactions with lipopolysaccharide and macrophages/monocytes

• Main Authors: Schmidtchen, Artur, Morgelin, Matthias, Hansen, Finja C., Kalle-Brune, Martina, van der Plas, Mariena J. A., Strömdahl, Ann-Charlotte, Malmsten, Martin
• Other Authors: Lee Kong Chian School of Medicine (LKCMedicine)
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences::Microbiology::Immunology
• Online Access: https://hdl.handle.net/10356/103339; http://hdl.handle.net/10220/25772
• Institution: Nanyang Technological University

Host defense peptides have recently gained much interest as novel anti-infectives owing to their ability to kill bacteria and simultaneously modulate host cell responses. The cationic host defense peptide GKY25 (GKYGFYTHVFRLKKWIQKVIDQFGE), derived from the C terminus of human thrombin, inhibits proi...