The thrombin-derived host defense peptide GKY25 inhibits endotoxin-induced responses through Interactions with lipopolysaccharide and macrophages/monocytes

• Main Authors: Schmidtchen, Artur, Morgelin, Matthias, Hansen, Finja C., Kalle-Brune, Martina, van der Plas, Mariena J. A., Strömdahl, Ann-Charlotte, Malmsten, Martin
• 其他作者: Lee Kong Chian School of Medicine (LKCMedicine)
• 格式: Article
• 語言: English
• 出版: 2015
• 主題: DRNTU::Science::Biological sciences::Microbiology::Immunology
• 在線閱讀: https://hdl.handle.net/10356/103339; http://hdl.handle.net/10220/25772

Host defense peptides have recently gained much interest as novel anti-infectives owing to their ability to kill bacteria and simultaneously modulate host cell responses. The cationic host defense peptide GKY25 (GKYGFYTHVFRLKKWIQKVIDQFGE), derived from the C terminus of human thrombin, inhibits proi...