Bis-(3'-5')-cyclic dimeric GMP regulates antimicrobial peptide resistance in pseudomonas aeruginosa

• Main Authors: Chua, Song Lin, Tan, Sean Yang-Yi, Rybtke, Morten Theil, Chen, Yicai, Rice, Scott A., Kjelleberg, Staffan, Tolker-Nielsen, Tim, Yang, Liang, Givskov, Michael
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2015
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/103682; http://hdl.handle.net/10220/25796
• Institution: Nanyang Technological University

Bis-(3′-5′)-cyclic dimeric GMP (c-di-GMP) is an intracellular second messenger that controls the lifestyles of many bacteria. A high intracellular level of c-di-GMP induces a biofilm lifestyle, whereas a low intracellular level of c-di-GMP stimulates dispersal of biofilms and promotes a planktonic l...