Beware of moving tagerts: reference proteome content fluctuates substantially over the years

• Main Authors: Sirota, Fernanda L., Batagov, Arsen, Schneider, Georg, Eisenhaber, Birgit, Eisenhaber, Frank, Maurer-Stroh, Sebastian
• Other Authors: School of Computer Engineering
• Format: Article
• Language: English
• Published: 2013
• Subjects: DRNTU::Engineering::Computer science and engineering::Computer applications::Life and medical sciences
• Online Access: https://hdl.handle.net/10356/103840; http://hdl.handle.net/10220/17113
• Institution: Nanyang Technological University

Reference proteomes are generated by increasingly sophisticated annotation pipelines as part of regular genome build releases; yet, the corresponding changes in reference proteomes' content are dramatic. In the history of the NCBI-curated human proteome, the total number of entries has remained...