The role of pro-inflammatory S100A9 in Alzheimer’s disease amyloid-neuroinflammatory cascade

• Main Authors: Zhao, Lina, Jia, Xueen, Shankar, S K, Olofsson, Anders, Brännström, Thomas, Mu, Yuguang, Gräslund, Astrid, Morozova-Roche, Ludmilla A, Jarvet, Jüri, Wang, Chao, Klechikov, Alexey G, Gharibyan, Anna L, Wärmländer, Sebastian K T S
• Other Authors: School of Biological Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Biological sciences
• Online Access: https://hdl.handle.net/10356/104026; http://hdl.handle.net/10220/19383
• Institution: Nanyang Technological University

Pro-inflammatory S100A9 protein is increasingly recognized as an important contributor to inflammation-related neurodegeneration. Here, we provide insights into S100A9 specific mechanisms of action in Alzheimer’s disease (AD). Due to its inherent amyloidogenicity S100A9 contributes to amyloid plaque...