Asymmetric access to the smallest enolate intermediate via organocatalytic activation of acetic ester

• Main Authors: Chen, Shaojin, Hao, Lin, Zhang, Yuexia, Tiwari, Bhoopendra, Chi, Robin Yonggui
• Other Authors: School of Physical and Mathematical Sciences
• Format: Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Science::Chemistry::Organic chemistry
• Online Access: https://hdl.handle.net/10356/104214; http://hdl.handle.net/10220/19450
• Institution: Nanyang Technological University

An NHC-catalyzed activation of acetic esters to afford enolate intermediates is disclosed. The catalytically generated triazolium enolate intermediates serve as two-carbon nucleophiles that undergo highly enantioselective reactions with enones and α,β-unsaturated imines to give α-unsubstituted δ-lac...