Copper(ii) complexes of substituted salicylaldehyde dibenzyl semicarbazones : synthesis, cytotoxicity and interaction with quadruplex DNA

• Main Authors: Klejevskaja, Beata, Munira Haidad Ali, Siti, Yan, Yaw-Kai, Lee, Peter P. F., Khong, Kenny Zhi Xiang, Alam Sk, Mahasin, Lim, Kok Hwa, Vilar, Ramon
• Other Authors: School of Chemical and Biomedical Engineering
• Format: Commentary Article
• Language: English
• Published: 2014
• Subjects: DRNTU::Engineering::Bioengineering
• Online Access: https://hdl.handle.net/10356/104460; http://hdl.handle.net/10220/20209
• Institution: Nanyang Technological University

A series of substituted salicylaldehyde dibenzyl semicarbazones [RC6H3(OH)CH[double bond, length as m-dash]N–NHCON(CH2Ph)2] and their copper(II) complexes were synthesized and characterized. The chloridocopper(II) complexes of the 4-OH and 5-OH substituted ligands (complexes 9 and 7) show modest aff...